Skip to main content

Table 5 Accuracy of CIMP prediction using gene expression profiles

From: Integrative DNA methylation and gene expression analysis to assess the universality of the CpG island methylator phenotype

 

Accuracy

 

Random

Lasso

Combined lasso

Group lasso

Bladder

62.8

62.9 (p = 1)

74.2 (p≤2.10−16)

72.1 (p≤2.10−16)

Breast

80.5

83.9 (p≤2.10−16)

84.7 (p≤2.10−16)

85.5 (p≤2.10−16)

Colon

79.4

79.5 (p = 1)

95.0 (p≤2.10−16)

94.2 (p≤2.10−16)

Lung

73.2

84.2 (p≤2.10−16)

76.2 (p≤2.10−16)

86.6 (p≤2.10−16)

Stomach

57.6

81.2 (p≤2.10−16)

83.0 (p≤2.10−16)

84.8 (p≤2.10−16)

Overall

71.9

82.4

82.6

85.0

  1. This table shows the accuracy, assessed by threefold cross-validation repeated 100 times over each tissue (first column), of sample classification in CIMP-positive and CIMP-negative classes from gene expression data using random classification (second column), lasso logistic regression (third column), combined lasso (fourth column), or group lasso logistic regression (fifth column)
Back to article page

Human Genomics

ISSN: 1479-7364