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Fig. 5 | Human Genomics

Fig. 5

From: Integrative genomic analysis reveals functional diversification of APOBEC gene family in breast cancer

Fig. 5

Gene expression and somatic mutation signatures in breast tumors stratified by copy numbers of APOBEC3B gene. a Boxplot of mRNA levels of APOBEC3B and APOBEC3C in totally 787 breast tumors. b Relationship between APOBEC3B (upper panel) and APOBEC3C (lower panel) expression levels and number of somatic SNVs per tumor exome. The red curves are drawn from the local regression smoothing. c Boxplot of the total number of somatic mutations per tumor exome (y-axis, log10 scaled). The color bars shown in the right are the original number of somatic SNVs per exome. d Frequency of each of six somatic mutation types. e Excess rate of trinucleotide motifs with centered C>A, C>G, and C>T mutations shown from left to right panels. The excess rate is calculated by (observed occurrence − mean occurrence) / mean occurrence. CN0, CN1, and CN2 present the zero, one, and two copies of APOBEC3B gene, respectively

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