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Fig. 5 | Human Genomics

Fig. 5

From: Intragraft transcriptional profiling of renal transplant patients with tubular dysfunction reveals mechanisms underlying graft injury and recovery

Fig. 5

Analysis of the intragraft transcriptional network related to proximal tubular dysfunction (PTD) right after enrollment (t0). Network genes were obtained by comparing the intragraft transcriptional profiles of patients with elevated uRBP levels and by subsequently inputting those genes in the GeneMania tool. a KEGG categories showing enrichment in functions for the network nodes. b Scatterplot of degree versus betweenness centralities for nodes obtained in the transcriptional network analysis. High-hubs, hubs, and bottlenecks are depicted respectively in royal blue, red, and oil blue colors. c Transcriptional subnetwork containing the most central nodes in the t0 network. Differentially expressed (DE) genes and DE-related genes are represented respectively as gray diamonds and blue circles in the network. Node sizes are based on betweenness centrality measurements. Genes previously associated with the keywords “immune response,” “T regulatory cells,” “autophagy,” or “ubiquitin-proteasome” are displayed in orange color

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