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Fig. 7 | Human Genomics

Fig. 7

From: The clinical trial landscape in oncology and connectivity of somatic mutational profiles to targeted therapies

Fig. 7

Connections between various data elements in the JAX Clinical Knowledgebase (JAX-CKB). Molecular profiles consist of one of more molecular entities, linked to gene variants and parent genes. Molecular profiles are assigned relevant treatment approaches based on available data from the literature on efficacy, as a therapeutic response. The therapeutic response additionally takes into account patient indication, which is represented by an integrated disease ontology. Treatment approaches contain therapies, which consist of a single drug or combination of drugs. These drugs can be either FDA-approved, or under investigation in clinical trials, which are additionally curated into the JAX-CKB

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