SNP | Genotype/alleles | Cases (N = 990) | Control (N = 618) | OR (95 % CI) | P value |
---|---|---|---|---|---|
rs2230806 (R219K) | RR | 291 | 195 | Ref | |
RK | 473 | 317 | 0.9 (0.79–1.25) | 0.999 | |
KK | 226 | 106 | 1.42 (1.06–1.91) | 0.017 | |
RK+KK | 699 | 423 | 1.10 (0.89–1.37) | 0.359 | |
R(G) | 1055 | 707 | Ref | ||
K(A) | 925 | 529 | 1.17 (1.01–1.35) | 0.029 | |
rs2066715 (V825I) | VV | 945 | 597 | Ref | |
VI | 45 | 21 | 1.35 (0.79–2.29) | 0.26 | |
II | 0 | 0 | – | – | |
VI+II | 45 | 21 | 1.35 (0.79–2.29) | 0.26 | |
V(G) | 1935 | 1215 | Ref | ||
I(A) | 45 | 21 | 1.34 (0.79–2.26) | 0.27 | |
rs5882 (V422I) | VV | 178 | 147 | Ref | |
VI | 523 | 297 | 1.45 (1.12–1.88) | 0.005 | |
II | 289 | 174 | 1.37 (1.02–1.82) | 0.031 | |
VI+II | 812 | 471 | 1.42 (1.11–1.82) | 0.005 | |
V(G) | 879 | 591 | Ref | ||
I(A) | 1101 | 645 | 1.14 (0.99–1.32) | 0.058 | |
rs708272 (TaqIB) | B1B1 | 376 | 183 | Ref | |
B1B2 | 454 | 321 | 0.68 (0.54–0.86) | 0.001 | |
B2B2 | 160 | 114 | 0.68 (0.50–0.92) | 0.012 | |
B1B2+B2B2 | 614 | 435 | 0.68 (0.55–0.85) | 0.0006 | |
B1(G) | 1206 | 687 | Ref | ||
B2(A) | 774 | 549 | 0.80 (0.69–0.92) | 0.003 |