Association of six CpG-SNPs in the inflammation-related genes with coronary heart disease

Table 2 Comparisons of genotype and allele frequencies between cases and controls

SNP	Groups	Genotype (counts)			χ ²	P (df = 2)	HWE P value^a	Allele (counts)		χ ²	P (df = 1)	OR (95 % CI)
IL1B rs16944		GG	AG	AA				G	A
	Cases	220	380	176			0.627	820	732
	Controls	173	379	180	4.387	0.112	0.335	725	739	3.310	0.069	1.142 (0.990–1.317)
IL1R2 rs2071008		GG	GT	TT				G	T
	Cases	434	285	65			0.064	1153	415
	Controls	417	275	46	2.382	0.304	0.941	1109	367	1.020	0.313	0.919 (0.781–1.082)
PLA2G7 rs9395208		GG	GC	CC				G	C
	Cases	565	198	21			0.468	1328	240
	Controls	568	154	17	4.603	0.100	0.095	1290	188	4.210	0.040	0.806 (0.657–0.991)
FAM5C rs12732361		GG	AG	AA				G	A
	Cases	492	242	49			0.011	1226	340
	Controls	431	254	52	3.022	0.221	0.088	1116	358	2.850	0.091	1.157 (0.977–1.370)
CD40 rs1800686		GG	AG	AA				G	A
	Cases	378	332	74			0.929	1088	480
	Controls	317	333	89	5.411	0.067	0.914	967	511	5.440	0.020	1.198 (1.029–1.394)
CD36 rs2065666		GG	GC	CC				G	C
	Cases	439	288	56			0.356	1166	400
	Controls	411	282	43	1.24	0.538	0.555	1104	368	0.120	0.729	0.972 (0.825–1.145)

^a HWE Hardy-Weinberg equilibrium; P value <0.05 was considered a departure from HWE

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