Fig. 4

Enrichment of C-DMRs in the regulatory regions. The ENCODE genome annotation datasets for Gm12878 lymphoblastoid cell line from Broad and Stanford/Yale/USC/Harvard were used for transcription factor and Histone enrichment analyses (a, b). Broad datasets were used for chromatin states enrichment (c). See Figures S3, S4 in Additional file 1 for the results for all cell lines. The vertical axis shows –log10-transformed enrichment p values, FDR corrected. Left/right parts of the bar-plots show top 10 most significant enrichments for hyper/hypo-C-DMRs, respectively. a Transcription factor binding sites enrichment. b Histone modification sites enrichment. c Chromatin states enrichment