Table 7 ADRB1 genotype
From: Multiplex SNaPshot—a new simple and efficient CYP2D6 and ADRB1 genotyping method
ADRB1 haplotype | Number of subjects | Frequencies (%) | Expected metoprolol clinical effect |
|---|---|---|---|
49Ser389Arg/49Ser389Arg | 30 | 25.2 | Threefold greater diastolic blood pressure reduction [7, 12] |
49Ser389Arg/49Gly389Arg | 8 | 6.7 | Good responder [12] |
49Ser389Gly/49Gly389Arg | 22 | 18.5 | |
49Ser389Gly/49Ser389Gly | 16 | 13.4 | |
49Ser389Gly/49Gly389Gly | 2 | 1.7 | Unknown, designated good responders by prior investigators [7, 12] |
49Ser389Gly/49Ser389Arg | 36 | 30.3 | Good responder [12] |
49Gly389Arg/49Gly389Arg | 5 | 4.2 | Unknown, designated good responders by prior investigators [7, 12] |