From: Organization, evolution and functions of the human and mouse Ly6/uPAR family genes
Approved protein symbol | Human ortholog? | Expression pattern | Interacting factors | Cellular function | Gene knockout? | GPI-anchor? | References |
---|---|---|---|---|---|---|---|
ACRV1 | Yes | Spermatazoa (acrosomes) | TARDBP (TDP-43) | Sperm-oolemma binding/penetration | No | No | |
CD177 | Yes | Neutrophils | PR3, PECAM1 | Neutrophil activation | Yes | Yes | |
CD59A | No | Neurons, T cells, splenic macrophages, spermatids | MAC Complex | Complement inhibitor | Yes | Yes | |
CD59B | Yes (as CD59) | Lymphocytes, granulocytes, platelets, erythrocytes, activated T cells, spermatazoa, splenic macrophages, mature spermatozoa | C8, C9 | Complement inhibition, cell-cell adhesion | Yes | Yes | |
GML | Yes | Cancer cells | TRP53 | Apoptosis | No | Yes | |
GML2 | No | Hematopoetic stem cells | Unknown | Unknown | No | Predicted No | [123] |
GPIHBP1 | Yes | Capillary endothelial cells | LPL | Chylomicron processing, LPL transport | Yes | Yes | |
LY6A | No | Hematopoetic stem cells, B cells, T cells, DCs | IFN-γ, MMPs | T cell activation and proliferation controller | Yes | Yes | |
LY6A2 | No | Unknown | Unknown | Unknown | No | Predicted Yes | Â |
LY6C1 | No | T cells, NK cells, monocytes, neutrophils, DCs, bone marrow myeloid cells | Type I and II interferons, LFA-1 | CD8+ T cell migration | No | Yes | [28] |
LY6C2 | No | T cells, NK cells, monocytes, neutrophils, DCs, bone marrow myeloid cells | Type I and II interferons, LFA-1 | CD8+ T cell migration | No | Yes | [28] |
LY6D | Yes | Keratinocytes, B cells | Camptothecin, mitomycin C, carboplatin, hydroxyurea, aphidicolin | Cell adhesion, B cell specification | No | Yes | |
LY6E | Yes | Myeloid cells, thymocytes | Retinoic acid, INF1 | Monocyte inhibitor, T cell development | No | Yes | |
LY6F | No | Non-lymphoid tissues | Unknown | Unknown | No | Predicted Yes | [140] |
LY6G | No | Neutrophils, granulocytes | LTB4, β2-integrins | Neutrophil recruitment | No | Yes | |
LY6G2 | No | Unknown | Unknown | Unknown | No | Predicted No | Â |
LY6G5B | Yes | Stomach, placenta | Unknown | Unknown | No | No | |
LY6G5C | Yes | Testis, fetal liver/spleen/retina/heart/thymus, MS lesions, germinal center B cells, carcinoid lung | Unknown | Hematopoietic cell differentiation | No | No | |
LY6G6C | Yes | Fibroblasts | Unknown | Filipodia functions | No | Yes | |
LY6G6D | Yes | Fibroblasts | Unknown | Filipodia functions | No | Yes | |
LY6G6E | No | Undifferentiated megakaryocyte-like cells | Unknown | α4β2 potentiator, cell adhesion and migration | No | Yes | |
LY6G6F | Yes | K562 acute myeloblastic leukemia cells | GRB2, GRB7 | Unknown | No | Predicted No | [144] |
LY6G6G | No | Unknown | Unknown | Unknown | No | Predicted No | Â |
LY6H | Yes | Exocrine and endocrine epithelial cells, CNS | Unknown | Unknown | No | Yes | |
LY6I | No | Monocytes, granulocytes, CD19+ B cells, thymocytes and T cells | Unknown | Unknown | No | Yes | |
LY6K | Yes | Keratinocytes, squamous cell carcinomas | JUND, FOSL1, RAS | Invasive cell metastasis | Yes | Yes | |
LY6L | Yes | Unknown | Unknown | Unknown | No | Predicted Yes | Â |
LY6M | No | Unknown | Unknown | Unknown | No | Predicted Yes | Â |
LYNX1 | Yes | CNS neurons | α4β2 and α7 nAChRs | nAChR modulator | Yes | Yes | |
LYPD1 | Yes | Airway epithelial cells, embryonic tissue, CNS and PNS neurons | α4β2, α4β4, and α7 nAChRs | α7 nAChR modulator, tumor suppression | Yes | Yes | |
LYPD2 | Yes | Unknown | α4β2 nAChRs | nAChR Modulator | No | Yes | [105] |
LYPD3 | Yes | Stratum spinosum keratinocytes, cancer cells | α6β4, MMP14 | Metastasis, EMT, wound healing | No | Yes | |
LYPD4 | Yes | Unknown | Unknown | Unknown | No | Predicted No | Â |
LYPD5 | Yes | Stratum granulosum keratinocytes | AP-1 | Unknown | No | Yes | |
LYPD6 | Yes | Ubiquitously | WNT3A | Tumor suppression | No | Yes | |
LYPD6B | Yes | Testis, lung, stomach, prostate | AP-1 | PKC signal transduction pathway | No | Yes | [165] |
LYPD8 | Yes | Unknown | Unknown | Unknown | No | Predicted Yes | Â |
LYPD9 | No | Unknown | Unknown | Unknown | No | Predicted Yes | Â |
LYPD10 | No | Unknown | Unknown | Unknown | No | Predicted Yes | Â |
LYPD11 | No | Unknown | Unknown | Unknown | No | Predicted Yes | Â |
PATE1 | Yes | Leydig cells, testicular germ cells, prostatic epithelial cells principle cells, spermatazoa, | INCA1 | Spermatazoa/egg fusion and penetration, spermatazoa motility | No | No | |
PATE2 | Yes | Spermatazoa, testicular germ cells, neuronal tissue | nAChR | nAChR modulator | No | No | |
PATE3 | Yes | Testis | nAChR | nAChR modulator | No | No | [29] |
PATE4 | Yes | Spermatazoa, prostatic apical epithelial cells, spinal cord tissue | α7 nAChR | nAChR modulator | Yes | No | |
PATE5 | No | Male reproductive organs | Androgens, lumicrine testicular factors | Unknown | No | No | |
PATE6 | No | Male reproductive organs | Androgens | nAChR regulator | No | No | |
PATE7 | No | Male reproductive organs | Androgens | Unknown | No | No | |
PATE8 | No | Male reproductive organs, skeletal muscle | Androgens | Unknown | No | No | |
PATE9 | No | Male reproductive organs | Unknown | Unknown | No | No | |
PATE10 | No | Male reproductive organs | Androgens, lumicrine testicular factors | Unknown | No | No | |
PATE11 | No | Placenta | α4β2 nAChR | α4β2 nAChR regulator | No | No | |
PATE12 | No | Placenta | Unknown | Unknown | No | No | |
PATE13 | No | Male reproductive organs | Androgens | Unknown | No | No | [29] |
PATE14 | No | Luminal epithelium of seminal vesicles | Androgens | Unknown | No | No | [169] |
PINLYP | Yes | Unknown | Unknown | Unknown | No | Predicted No | Â |
PLAUR | Yes | Airway epithelial cells, trophoblast cells, cancerous cells, HUVEC, pan-epithelial | uPA, Mac-1, caveolin, SERPINE1, vitronectin, kininogen, thrombospondin, α2-macroglobulin receptor, MRC2, cation-independent mannose 6-phosphate/insulin-like growth factor II receptor | Fibrinolysis, matrix remodeling, cell migration, growth factor activation, integrin regulation, tumor cell invasion, cell adhesion | Yes | Yes | |
PSCA | Yes | Prostate basal cells, epithelial cells of prostate, urinary bladder, kidney, skin, esophagus, stomach, and placenta, cortical cells | SNAI2, α4 nAChR | Tumor suppression, oncogene, nAChR modulator | Yes | Yes | |
SLURP1 | Yes | Keratinocytes, mucocutaneous and aerodigestive epithelia, some C-fiber neurons | α7 nAChR, KLF4 | Tumor suppression, nAChR modulator | Yes | No | |
SLURP2 | Yes | Oral and epidermal keratinocytes | α3 nAChR | nAChR modulator, blocks apoptosis | Yes | No | |
SPACA4 | Yes | Spermatazoa | Unknown | Spermatazoa-egg binding/fusion | No | Yes | [194] |
TEX101 | Yes | Spermatazoa, cancerous tissues | Progesterone, PLAU | Spermatazoaatogenesis, spermatazoa-egg interaction, protease suppressor | Yes | Yes |