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Table 3 Expression patterns, interacting factors and cellular functions of mouse Ly6/uPAR family proteins

From: Organization, evolution and functions of the human and mouse Ly6/uPAR family genes

Approved protein symbol

Human ortholog?

Expression pattern

Interacting factors

Cellular function

Gene knockout?

GPI-anchor?

References

ACRV1

Yes

Spermatazoa (acrosomes)

TARDBP (TDP-43)

Sperm-oolemma binding/penetration

No

No

[29, 31, 109–111]

CD177

Yes

Neutrophils

PR3, PECAM1

Neutrophil activation

Yes

Yes

[46, 47, 112–114]

CD59A

No

Neurons, T cells, splenic macrophages, spermatids

MAC Complex

Complement inhibitor

Yes

Yes

[115–118]

CD59B

Yes (as CD59)

Lymphocytes, granulocytes, platelets, erythrocytes, activated T cells, spermatazoa, splenic macrophages, mature spermatozoa

C8, C9

Complement inhibition, cell-cell adhesion

Yes

Yes

[17, 48, 56, 67, 118–120]

GML

Yes

Cancer cells

TRP53

Apoptosis

No

Yes

[121, 122]

GML2

No

Hematopoetic stem cells

Unknown

Unknown

No

Predicted No

[123]

GPIHBP1

Yes

Capillary endothelial cells

LPL

Chylomicron processing, LPL transport

Yes

Yes

[62, 63, 124]

LY6A

No

Hematopoetic stem cells, B cells, T cells, DCs

IFN-γ, MMPs

T cell activation and proliferation controller

Yes

Yes

[28, 125–129]

LY6A2

No

Unknown

Unknown

Unknown

No

Predicted Yes

 

LY6C1

No

T cells, NK cells, monocytes, neutrophils, DCs, bone marrow myeloid cells

Type I and II interferons, LFA-1

CD8+ T cell migration

No

Yes

[28]

LY6C2

No

T cells, NK cells, monocytes, neutrophils, DCs, bone marrow myeloid cells

Type I and II interferons, LFA-1

CD8+ T cell migration

No

Yes

[28]

LY6D

Yes

Keratinocytes, B cells

Camptothecin, mitomycin C, carboplatin, hydroxyurea, aphidicolin

Cell adhesion, B cell specification

No

Yes

[130–134]

LY6E

Yes

Myeloid cells, thymocytes

Retinoic acid, INF1

Monocyte inhibitor, T cell development

No

Yes

[135–139]

LY6F

No

Non-lymphoid tissues

Unknown

Unknown

No

Predicted Yes

[140]

LY6G

No

Neutrophils, granulocytes

LTB4, β2-integrins

Neutrophil recruitment

No

Yes

[28, 109, 141]

LY6G2

No

Unknown

Unknown

Unknown

No

Predicted No

 

LY6G5B

Yes

Stomach, placenta

Unknown

Unknown

No

No

[142, 143]

LY6G5C

Yes

Testis, fetal liver/spleen/retina/heart/thymus, MS lesions, germinal center B cells, carcinoid lung

Unknown

Hematopoietic cell differentiation

No

No

[142, 143]

LY6G6C

Yes

Fibroblasts

Unknown

Filipodia functions

No

Yes

[142, 143]

LY6G6D

Yes

Fibroblasts

Unknown

Filipodia functions

No

Yes

[142, 143]

LY6G6E

No

Undifferentiated megakaryocyte-like cells

Unknown

α4β2 potentiator, cell adhesion and migration

No

Yes

[105, 142]

LY6G6F

Yes

K562 acute myeloblastic leukemia cells

GRB2, GRB7

Unknown

No

Predicted No

[144]

LY6G6G

No

Unknown

Unknown

Unknown

No

Predicted No

 

LY6H

Yes

Exocrine and endocrine epithelial cells, CNS

Unknown

Unknown

No

Yes

[145, 146]

LY6I

No

Monocytes, granulocytes, CD19+ B cells, thymocytes and T cells

Unknown

Unknown

No

Yes

[28, 147]

LY6K

Yes

Keratinocytes, squamous cell carcinomas

JUND, FOSL1, RAS

Invasive cell metastasis

Yes

Yes

[148–152]

LY6L

Yes

Unknown

Unknown

Unknown

No

Predicted Yes

 

LY6M

No

Unknown

Unknown

Unknown

No

Predicted Yes

 

LYNX1

Yes

CNS neurons

α4β2 and α7 nAChRs

nAChR modulator

Yes

Yes

[25, 66, 73, 153]

LYPD1

Yes

Airway epithelial cells, embryonic tissue, CNS and PNS neurons

α4β2, α4β4, and α7 nAChRs

α7 nAChR modulator, tumor suppression

Yes

Yes

[103, 104, 154, 155]

LYPD2

Yes

Unknown

α4β2 nAChRs

nAChR Modulator

No

Yes

[105]

LYPD3

Yes

Stratum spinosum keratinocytes, cancer cells

α6β4, MMP14

Metastasis, EMT, wound healing

No

Yes

[156–160]

LYPD4

Yes

Unknown

Unknown

Unknown

No

Predicted No

 

LYPD5

Yes

Stratum granulosum keratinocytes

AP-1

Unknown

No

Yes

[156, 161]

LYPD6

Yes

Ubiquitously

WNT3A

Tumor suppression

No

Yes

[162–164]

LYPD6B

Yes

Testis, lung, stomach, prostate

AP-1

PKC signal transduction pathway

No

Yes

[165]

LYPD8

Yes

Unknown

Unknown

Unknown

No

Predicted Yes

 

LYPD9

No

Unknown

Unknown

Unknown

No

Predicted Yes

 

LYPD10

No

Unknown

Unknown

Unknown

No

Predicted Yes

 

LYPD11

No

Unknown

Unknown

Unknown

No

Predicted Yes

 

PATE1

Yes

Leydig cells, testicular germ cells, prostatic epithelial cells principle cells, spermatazoa,

INCA1

Spermatazoa/egg fusion and penetration, spermatazoa motility

No

No

[29, 32, 166–168]

PATE2

Yes

Spermatazoa, testicular germ cells, neuronal tissue

nAChR

nAChR modulator

No

No

[29, 31]

PATE3

Yes

Testis

nAChR

nAChR modulator

No

No

[29]

PATE4

Yes

Spermatazoa, prostatic apical epithelial cells, spinal cord tissue

α7 nAChR

nAChR modulator

Yes

No

[29, 33]

PATE5

No

Male reproductive organs

Androgens, lumicrine testicular factors

Unknown

No

No

[29, 30]

PATE6

No

Male reproductive organs

Androgens

nAChR regulator

No

No

[29, 30]

PATE7

No

Male reproductive organs

Androgens

Unknown

No

No

[29, 30]

PATE8

No

Male reproductive organs, skeletal muscle

Androgens

Unknown

No

No

[29, 30]

PATE9

No

Male reproductive organs

Unknown

Unknown

No

No

[29, 30]

PATE10

No

Male reproductive organs

Androgens, lumicrine testicular factors

Unknown

No

No

[29, 30]

PATE11

No

Placenta

α4β2 nAChR

α4β2 nAChR regulator

No

No

[29, 30]

PATE12

No

Placenta

Unknown

Unknown

No

No

[29, 30]

PATE13

No

Male reproductive organs

Androgens

Unknown

No

No

[29]

PATE14

No

Luminal epithelium of seminal vesicles

Androgens

Unknown

No

No

[169]

PINLYP

Yes

Unknown

Unknown

Unknown

No

Predicted No

 

PLAUR

Yes

Airway epithelial cells, trophoblast cells, cancerous cells, HUVEC, pan-epithelial

uPA, Mac-1, caveolin, SERPINE1, vitronectin, kininogen, thrombospondin, α2-macroglobulin receptor, MRC2, cation-independent mannose 6-phosphate/insulin-like growth factor II receptor

Fibrinolysis, matrix remodeling, cell migration, growth factor activation, integrin regulation, tumor cell invasion, cell adhesion

Yes

Yes

[23, 170–185]

PSCA

Yes

Prostate basal cells, epithelial cells of prostate, urinary bladder, kidney, skin, esophagus, stomach, and placenta, cortical cells

SNAI2, α4 nAChR

Tumor suppression, oncogene, nAChR modulator

Yes

Yes

[26, 57–59, 61, 150, 186–188]

SLURP1

Yes

Keratinocytes, mucocutaneous and aerodigestive epithelia, some C-fiber neurons

α7 nAChR, KLF4

Tumor suppression, nAChR modulator

Yes

No

[20, 76, 79, 94, 99, 189–192]

SLURP2

Yes

Oral and epidermal keratinocytes

α3 nAChR

nAChR modulator, blocks apoptosis

Yes

No

[99–102, 193]

SPACA4

Yes

Spermatazoa

Unknown

Spermatazoa-egg binding/fusion

No

Yes

[194]

TEX101

Yes

Spermatazoa, cancerous tissues

Progesterone, PLAU

Spermatazoaatogenesis, spermatazoa-egg interaction, protease suppressor

Yes

Yes

[151, 195–198]