Exploring the interaction among EPHX1, GSTP1, SERPINE2, and TGFB1 contributing to the quantitative traits of chronic obstructive pulmonary disease in Chinese Han population

Table 1 Single marker effects for six^a COPD-related quantitative traits (n = 310 patients)

Six COPD-related quantitative traits
FEV₁			FEV₁%pre			FVC			FEV₁/FVC (%)			BODE			6MWT
Main effects	p*	p**	Main effects	p*	p**	Main effects	p*	p**	Main effects	p*	p*	Main effects	p*	p**	Main effects	p*	p**
SERPINE2 (rs729631)	0.004	0.176	EPHX1 (rs868966)	0.048	1.000	EPHX1 (rs868966)	0.010	0.440	EPHX1 (rs3738040)	0.005	0.220	SERPINE2 (rs4674841)	0.008	0.352	EPHX1 (rs3766934)	0.027	1.000
SERPINE2 (rs975278)	0.016	0.704				EPHX1 (rs2854450)	0.022	0.968	EPHX1 (rs1877724)	0.007	0.308	EPHX1 (rs2234922)	0.019	0.836	SERPINE2 (rs4674841)	0.045	1.000
SERPINE2 (rs4674841)	0.037	1.000				EPHX1 (rs3738040)	0.023	1.000	EPHX1 (rs2292558)	0.015	0.660	GSTP1 (rs1138272)	0.020	0.880	SERPINE2 (rs6734100)	0.046	1.000
SERPINE2 (rs17196253)	0.013	0.572				EPHX1 (rs1877724)	0.045	1.000	GSTP1 (rs1138272)	0.028	1.000	SERPINE2 (rs13392495)	0.025	1.000
SERPINE2 (rs3820766)	0.029	1.000				SERPINE2 (rs729631)	2.27E-05	0.001	SERPINE2 (rs729631)	0.002	0.088	SERPINE2 (rs2118409)	0.032	1.000
									SERPINE2 (rs975278)	0.035	1.000	GSTP1 (rs36211088)	0.032	1.000

^aThere was no significant main effect for MMRC before being corrected by Bonferroni procedure
*p < 0.05 before corrected by Bonferroni procedure; **p after corrected by Bonferroni procedure

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