Table 3 The best two-way models identified by QMDR and GMDR for four lung-function-related quantitative traits in Chinese Han population (n = 310 patients + 203 controls)
COPD-related quantitative traits | The best two-way interaction models based on QMDR | The best two-way interaction models based on GMDR | ||||
|---|---|---|---|---|---|---|
Gene-gene interaction | CV consistency | Permutated P value | Gene-gene interaction | CV consistency | Permutated P value | |
FEV1 | rs2260863(EPHX1)*rs4147581(GSTP1) | 5/10 | 0.031* | rs3766934(EPHX1)*rs947895(GSTP1) | 3/10 | NS |
FEV1%pre | rs10151740(EPHX1)*rs1800469(TGFB1) | 2/10 | NS | rs2260863(EPHX1)*rs861442(SERPINE2) | 3/10 | NS |
FVC | rs7583463(SERPINE2)*rs2241713(TGFB1) | 5/10 | NS | rs6748795(SERPINE2)*rs2241713(TGFB1) | 4/10 | 0.036* |
FEV1/FVC (%) | rs17196253(SERPINE2)*rs2241713(TGFB1) | 8/10 | 0.027* | rs729631(SERPINE2)*rs2241713(TGFB1) | 2/10 | NS |