Table 5 The best three-way models identified by QMDR and GMDR for four lung-function-related quantitative traits in Chinese Han population (n = 310 patients + 203 controls)
COPD-related quantitative traits | The best three-way interaction models based on QMDR | The best three-way interaction models based on GMDR | ||||
|---|---|---|---|---|---|---|
Gene-gene interactions | CV consistency | Permutated P value | Gene-gene interactions | CV consistency | Permutated P value | |
FEV1 | rs4147581(GSTP1)*rs2260863(EPHX1)*rs6736436(SERPINE2) | 4/10 | NS | rs868966(EPHX1)*rs7583463(SERPINE2)*rs947895(GSTP1) | 4/10 | NS |
FEV1%pre | rs282254(SERPINE2)*rs6738983(SERPINE2)*rs2241713(TGFB1) | 4/10 | 0.041* | rs282254(SERPINE2)*rs729631(SERPINE2)*rs1051740(EPHX1) | 2/10 | NS |
FVC | rs2241715(TGFB1)*rs282254(SERPINE2)*rs6738983(SERPINE2) | 2/10 | NS | rs2241713(TGFB1)*rs6748795(SERPINE2)*rs7579646(SERPINE2) | 4/10 | 0.035* |
FEV1/FVC (%) | rs10191694(SERPINE2)*rs868966(EPHX1)*rs2241713(TGFB1) | 4/10 | NS | rs4674843(SERPINE2)*rs282254(SERPINE2)*rs2241713(TGFB1) | 5/10 | 0.039* |