From: AMD and the alternative complement pathway: genetics and functional implications
Inflammation and immune response | Cell stress response | ||||||
C2 | Complement component 2 | HLA-C | Major histocompatibility complex, class I, C | ABCA4 | ATP-binding cassette subfamily A member 4 | HTRA1 | HtrA serine peptidase 1 |
C3 | Complement component 3 | IL8 | Interleukin B | ACE | Angiotensin I converting enzyme 1 | RORA | RAR-related orphan receptor alpha |
CFB | Complement factor B | MMP9 | Matrix metallopeptidase 9 | APOE | Apoliporotein E | SOD2 | Superoxide dismutase 2, mitochondrial |
CFH | Complement factor H | PLEKHA1 | Pleckstrin homology domain containing, family A member 1 | ARMS2 | Age-related maculopathy susceptibility 2 | TF | Transferrin |
CFD | Complement factor D | RORA | RAR-related orphan receptor alpha | CST3 | Cystatin C | TLR3 | Toll-like receptor 3 |
CFHR1-5 | Complement factor H-related 1-5 | SERPING1 | Serpin peptidase inhibitor, clade G, member 1 | CX3CR1 | Chemokine receptor 1 | TLR4 | Toll-like receptor 4 |
CFI | Complement factor I | TLR3 | Toll-like receptor 3 | CYP24A1 | Cytochrome P450, family 24, subfamily A peptide 1 | VLDLR | Very low-density lipoprotein receptor |
C9 | Complement component 9 | TLR4 | Toll-like receptor 4 | GSTM1 | Glutathione S-transferase mu 1 | TNFRSF10A/LOC389641 | Tumor necrosis factor receptor superfamily, member 10a |
CX3CR1 | Chemokine receptor 1 | VLDLR | Very low-density lipoprotein receptor | GSTP1 | Glutathione S-transferase pi 1 | IER3 | Immediate early response 3 |
F13B | Coagulation factor XIII, B polypeptide | VTN | Vitronectin | GSTT1 | Glutathione S-transferase tau 1 | TGFBR1 | Transforming growth factor, beta receptor 1 |
Lipid metabolism and transport | Extracellular matrix and cell adhesion | ||||||
ABCA1 | ATP-binding cassette, subfamily A, member 1 | FADS1-3 | Fatty acid desaturases 1-3 | ACE | Angiotensin 1 converting enzyme 1 | ROBO1 | Roundabout, axon guidance receptor, homolog 1 |
ABCA4 | ATP-binding cassette, subfamily A, member 4 | LIPC | Hepatic lipase | ARMS2 | Age-related maculopathy susceptibility 2 | TIMP3 | Tissue inhibitor of metalloproteinase 3 |
APOE | Apolipoprotein E | LPL | Lipoprotein lipases | ADAMTS9 | ADAM metallopeptidase with trhombospondin type 1 motif, 9 | MMP19 | Matrix metallopeptidase 19 |
CETP | Cholesteryl ester transfer protein, plasma | LRP6 | Low-density lipoprotein receptor-related protein 6 | COL8A1 | Collagen, type VIII, alpha 1 | PCOLCE | Procollagen c-endopeptidase enhancer |
CFHR1-5 | Complement factor H-related 1-5 | RORA | RAR-related orphan receptor alpha | COL10A1 | Collagen, type X, alpha 1 | VTN | Vitronectin |
CYP24A1 | Cytochrome P450, family 24, subfamily A peptide 1 | VLDLR | Very low-density lipoprotein receptor | CST3 | Cystatin C | ABCA7 | ATP-binding cassette, cubfamily A, member 7 |
ELOVL4 | ELVL fatty acid elongase 4 | PLTP | Phospholipid transfer protein | CX3CR1 | Chemokine receptor 1 | ACTG1 | Actin gamma 1 |
Angiogenesis | F13B | Coagulation factor XIII, B polypeptide | BCAR1 | Breast cancer anti-estrogen resistance 1 | |||
ACE | Angiotensin I converting enzyme 1 | LRP6 | Low-density lipoprotein receptor-related protein 6 | FBLN5 | Fibulin 5 | COL4A4 | Collagen, type IV, alpha 4 |
COL10A1 | Collagen, type X, alpha 1 | MMP9 | Matrix metallopeptidase 9 | HMCN1 | Hemicentin | ITGA7 | Integrin, alpha 7 |
COL8A1 | Collagen, type VIII, alpha 1 | RORA | RAR-related orphan receptor alpha | HTRA1 | HtrA serine peptidase 1 | MYL2 | Myosin, light chain 2, regulatory, cardiac, slow |
CST3 | Cystatin C | SERPINF1 | Serpin peptidase inhibitor, clade F | MMP9 | Matrix metallopeptidase 1 | Â | Â |
FBLN5 | Fibulin 5 | TIMP3 | Tissue inhibitor of metalloproteinase 3 | Â | Â | Â | Â |
GDF6 | Growth differentiation factor 6 | VEGFA | Vascular endothelial growth factor A | Â | Â | Â | Â |
HTRA1 | HtrA serine peptidase 1 | VLDLR | Very low-density lipoprotein receptor | Â | Â | Â | Â |
IL8 | Interleukin 8 | Â | Â | Â | Â | Â | Â |