MicroRNAs in acute kidney injury

Fan, Pei-Chun; Chen, Chia-Chun; Chen, Yung-Chang; Chang, Yu-Sun; Chu, Pao-Hsien

doi:10.1186/s40246-016-0085-z

Human Genomics

Table 1 miRNAs implicated in acute kidney injury

From: MicroRNAs in acute kidney injury

miRNA	Samples	Species	Model	Expression	Reference
k12-3	In vitro	HK-2 cells	Oxidative stress	Down then up	[51]
let-7a	T, B	Rat, human	Contrast nephropathy, contrast nephropathy^a	Down	[52]
let-7a-1-3p	T, U	Rat	Cisplatin nephropathy	Up (urine), down (tissue)	[33]
let-7a-2*	In vitro	HK-2 cells, primary PTCs	AA nephropathy	Up	[38]
let-7b	B	Human	ICU AKI^a	Down	[46]
let-7d	U	Rat	Gentamicin nephropathy	Down	[53]
let-7e	T, in vitro	Mouse, HK-2 cells	IRI	Up, down	[23, 54]
let-7f	B, T	Human, mouse	ICU AKI^a, IRI	Down	[34, 46]
let-7g	T, U	Mouse, rat	Cisplatin nephropathy	Up, down	[33, 35]
miR-7	T, in vitro	Mouse, HK-2 cells	IRI, oxidative stress	Up	[14, 51]
miR-7a-1-3p	T, U	Rat	Cisplatin nephropathy	Up (urine), down (tissue)	[33]
miR-10a	T, U, B	Mouse, human, rat	IRI, DM-CKD (STZ), FSGS^a, ICU AKI^a	Up, down	[15, 16, 18]
miR-10b*	T	Mouse	Cisplatin nephropathy	Down	[35]
miR-15	U	Rat	Cisplatin nephropathy	Up	[55]
miR-15b-5p	T, in vitro	Mouse, HK-2 cells	IRI	Down	[54]
miR-16	B, U	Human, rat	ICU AKI^a, cisplatin nephropathy	Up, down	[46, 55]
miR-17-3p	T	Mouse	IRI	Up	[14, 49]
miR-17-5p	T, U	Mouse, rat	IRI, cisplatin nephropathy	Up, down	[19, 20, 33]
miR-18a	T, B, U, in vitro	Mouse, rat, human, HPTECs	IRI, gentamicin nephropathy, folic acid, CdCl₂, arsenic trioxide, AA, K₂Cr₂O₇, cisplatin, UUO, allograft rejection^a, renal fibrosis^a	Up, down	[14, 34, 47, 56, 57]
miR-19a	T	Mouse	IRI	Up	[34]
miR-20a	T, in vitro, U	Mouse, TECs, rat, HK-2 cells	Cisplatin nephropathy, IRI	Up, down	[37, 54, 55]
miR-20b-5p	T, U, in vitro	Rat, mouse, HK-2 cells	Cisplatin nephropathy, IRI	Up (urine), down (tissue)	[33, 54]
miR-21	B, U, T, in vitro	Human, rat, mouse, TEC, CRL-2753 cells, NRK52E cells, HK-2 cells	IRI, TGF-β, anti-Thy 1.1, UUO, SHRSP, gentamicin nephropathy, folic acid, CdCl₂, arsenic trioxide, AA, K₂Cr₂O₇, allograft rejection^a, renal fibrosis^a, AKI^a	Up, down	[19–30, 34, 37, 45, 56–58]
miR-24	B, T, in vitro	Human, rat, CRL-2753 cells, NRK52E cells, HK-2 cells, HUVECs	ICU AKI^a, transplantation^a, UUO, IRI	Up, down	[31, 45, 46]
miR-24-2	T	Mouse	IRI	Up	[34]
miR-25-3p	T, U	Rat	Cisplatin nephropathy	Up (urine), down (tissue)	[33]
miR-26a	In vitro, T	HK-2 cells, mouse	IRI, oxidative stress, cisplatin nephropathy	Down	[32, 35, 51]
miR-26b	T, in vitro, U, B	Rat, CRL-2753 cells, NRK52E cells, human	UUO, cisplatin nephropathy, ICU AKI^a	Down (tissue, blood), up (urine)	[18, 33, 45]
miR-27a-3p	B	Human	ICU AKI^a	Down	[18]
miR-29a	T, in vitro, B	HK-2 cells, human	Oxidative stress, ICU AKI^a	Up, down	[18, 51, 59]
miR-29b	T, in vitro	Rat, HK-2 cells	Oxidative stress	Up	[51, 59]
miR-29c	T	Mouse	IRI	Up	[34, 59]
miR-30a-5p	T, U, in vitro, B	Rat, mouse, HK-2 cells, human	Cisplatin nephropathy, IRI, contrast-induced nephropathy, contrast-induced nephropathy^a	Up (urine, blood, tissue), down (tissue)	[33, 52, 54]
miR-30c	T, in vitro, B	Rat, CRL-2753 cells, NRK52E cells, mouse, human	TGF-β, UUO, SHRSP, contrast-induced nephropathy, contrast-induced nephropathy^a	Up, down	[34, 45, 52]
miR-30c-1	T	Mouse	IRI	Up	[34]
miR-30c-2*	In vitro	HK-2 cells	Oxidative stress	Down	[51]
miR-30d	T, U, B	Mouse, human	IRI, DM-CKD (STZ), FSGS^a	Up, down, unchanged	[16]
miR-30d*	B	Human	ICU AKI^a	Down	[46]
miR-30e	T, B	Mouse, rat, human	Cisplatin nephropathy, contrast-induced nephropathy, contrast-induced nephropathy^a	Up, down	[35, 52]
miR-34a	T, in vitro	Mouse, BUMPT-306 cells, NRK-52E cells, RTECs	Cisplatin nephropathy, IRI	Up	[35, 60, 61]
miR-34b	T	Mouse	IRI	Up	[47]
miR-92a	T	Mouse	IRI	Up	[34]
miR-92b*	B	Human	ICU AKI^a	Up	[46]
miR-93-3p	B	Human	ICU AKI^a, AKI post-cardiac surgery^a	Down	[18]
miR-93-5p	T, U	Rat	Cisplatin nephropathy	Up (urine), down (tissue)	[33]
miR-99b	In vitro, T	HK-2 cells, mouse	ER stress, IRI	Down	[51, 54]
miR-101-3p	B	Human	ICU AKI^a	Down	[18]
miR-101a	T, in vitro	Mouse, HK-2 cells	UUO	Down	[25]
miR-106a-5p	T, in vitro	Mouse, HK-2 cells, primary PTCs, rat	IRI, AA nephropathy	Up, down	[19, 20, 38]
miR-122	T	Mouse	Cisplatin nephropathy, IRI	Down	[35, 49]
miR-123	T	Mouse	IRI	Up	[49]
miR-125a-5p	T, in vitro	Mouse, HK-2 cells	IRI	Down	[54]
miR-125b	T, in vitro	Mouse, HepG2 cells, HEK293 cells, NRK52E cells	Cisplatin nephropathy		[62]
miR-126-3p	B	Human	ICU AKI^a	Down	[18]
miR-126-5p	T, in vitro	Mouse, rat, TEnCs, TEpCs	IRI	Up	[34, 43, 44, 63]
miR-127-3p	T, in vitro, B	Rat, mouse, NRK-52E cells, HK-2 cells, human	IRI, ICU AKI^a, AKI post-cardiac surgery^a	Up, down	[14, 18, 36, 49]
miR-129-3p	T	Mouse	IRI	Up	[34]
miR-129-5p	In vitro	HK-2 cells, primary PTCs	AA nephropathy	Down	[38]
miR-130b-3p	T, U	Rat	Cisplatin nephropathy	Up (urine), down (tissue)	[33]
miR-132	T, in vitro	Mouse, human, HPTECs	IRI, folic acid, CdCl₂, arsenic trioxide, AA, K₂Cr₂O₇, cisplatin, UUO, allograft rejection^a, renal fibrosis^a	Up	[14, 57]
miR-133a	In vitro	HK-2 cells	ER stress	Down	[51]
miR-134	T	Mouse	IRI	Up	[47]
miR-135b	T	Mouse	IRI	Down	[14, 49]
miR-140-3p	T, U	Rat	Cisplatin nephropathy	Up (urine), down (tissue)	[33]
miR-141	T	Mouse	IRI	Up	[34]
miR-142-3p	T, in vitro	Mouse, HK-2 cells	UUO	Up	[25]
miR-142-5p	T, in vitro	Mouse, HK-2 cells	UUO	Up	[25]
miR-145	T, in vitro	Rat, mouse, CRL-2753 cells, NRK52E cells, CD133+ renal medullary progenitor cells	TGF-β, SHRSP salt challenge	Up, down	[39, 45, 64]
miR-146a	T, in vitro, B	Mouse, TECs, human	IRI, ICU AKI^a	Down (blood), up (tissue)	[18, 37]
miR-146b-5p	T, in vitro	Mouse, human, HPTECs	IRI, folic acid, CdCl₂, arsenic trioxide, AA, K₂Cr₂O₇, cisplatin, UUO, allograft rejection^a, renal fibrosis^a	Up	[57]
miR-149	T	Mouse	IRI	Down	[34]
miR-150	T, in vitro	Mouse, immortalized mouse cardiac endothelial cell lines	IRI, AMI using LAD ligation	Down	[65]
miR-155	B, U, T, in vitro	Rat, human, mouse, HK-2 cells	IRI, gentamicin nephropathy, Cisplatin nephropathy, AKI^a	Up, down	[54, 56, 66]
miR-181a*	In vitro	HK-2 cells	ER stress	Up	[51]
miR-181a-2*	In vitro	HK-2 cells	ER stress	Down	[51]
miR-181d	T	Mouse	IRI	Down	[34]
miR-182	T	Mouse	IRI	Up	[47]
miR-183-5p	T, U	Rat	Cisplatin nephropathy	Up (urine), down (tissue)	[33]
miR-187	T, in vitro	Mouse, TECs	IRI	Down	[37]
miR-188-5p	T	Mouse	IRI	Up	[34]
miR-191a-5p	T, U	Rat	Cisplatin nephropathy	Up (urine), down (tissue)	[33]
miR-192	T, in vitro, B, U	Mouse, rat, CRL-2753 cells, NRK52E cells, TECs, HK-2 cells, primary PTCs	IRI, UUO, SHRSP, AA nephropathy, cisplatin nephropathy, contact freezing, Dahl salt-sensitive rat with high salt administration	Up, down	[15, 33, 45, 55]
miR-193	T, in vitro, U	Mouse, HK-2 cells, Rat	UUO, cisplatin nephropathy	Down (tissue), up (urine)	[25, 33, 35, 55]
miR-194	T, in vitro, B, U	Mouse, rat, TECs, HK-2 cells, primary PTCs	IRI, AA nephropathy, contact freezing, Dahl salt-sensitive rat with high salt administration	Up, down	[15, 37–39]
miR-197	T	Mouse	IRI	Down	[34]
miR-199a-3p	T, in vitro	Mouse, TECs	IRI	Up	[37]
miR-200a	T, B, U	Human, Rat, mouse	Contact freezing, Dahl salt-sensitive rat with high salt administration, contrast-induced nephropathy, contrast-induced nephropathy^a	Up, down	[39, 52]
miR-200b	T, in vitro, B, U	Rat, CRL-2753 cells, NRK52E cells, human	TGF-β, UUO, contact freezing, early CKD (Dahl salt-sensitive rat with high salt administration)	Up, down	[34, 39, 45]
miR-200c	T, in vitro, U, B	Rat, CRL-2753 cells, NRK52E cells, human	TGF-β, contact freezing, early CKD (Dahl salt-sensitive rat with high salt administration), ICU and transplant AKI^a	Up, down	[29, 39, 45]
miR-202	In vitro	HK-2 cells	ER stress	Down	[51]
miR-203	U	Rat	Gentamicin nephropathy	Down	[53]
miR-205	In vitro	HK-2 cells, primary PTCs	Oxidative stress, ER stress, AA nephropathy	Down	[38, 51]
miR-207	T	Mouse	IRI	Up, down	[14, 34]
miR-210	B, T, in vitro, U	Human, mouse, HUVEC-12 cells, HK-2 cells, primary PTCs, rat	IRI, Oxidative stress, AA nephropathy, cisplatin nephropathy, ICU AKI^a	Up, down	[18, 34, 38, 46, 47, 51, 55]
miR-211	T	Mouse	IRI	Down	[34]
miR-212	T	Mouse, human, HPTECs	IRI, folic acid, CdCl₂, arsenic trioxide, AA, K₂Cr₂O₇, cisplatin, UUO, allograft rejection^a, renal fibrosis^a	Up, down	[34, 57]
miR-214	T, in vitro	Mouse, rat, HK-2 cells, TECs, CRL-2753 cells, NRK52E cells, human	TGF-β, anti-Thy 1.1, UUO, SHRSP, IRI, diabetic nephropathy^a	Up	[23–25, 37, 45, 47]
miR-215	In vitro	HK-2 cell	ER stress	Down	[51]
miR-218	T, in vitro	Mouse, HK-2 cells	UUO	Down	[25]
miR-218-1	T	Mouse	IRI	Up	[34]
miR-218a-5p	T, U	Rat	Cisplatin nephropathy	Up (urine),down (tissue)	[33]
miR-221*	In vitro	HK-2 cells	Oxidative stress	Up	[51]
miR-223	T, in vitro	Mouse, HK-2 cells	UUO	Up	[25]
miR-290-3p	T	Mouse	IRI	Up	[34]
miR-296	T, in vitro	Rat, mouse, TEnCs, TEpCs	IRI	Up, down	[14, 43]
miR-302b	T	Mouse	IRI	Up	[34]
miR-302c	T	Mouse	IRI	Up	[34]
miR-320	B, T, U	Human, mouse, rat	IRI, cisplatin nephropathy, gentamicin nephropathy, contrast-induced nephropathy, ICU AKI^a, contrast-induced nephropathy^a	Up, down	[23, 33, 34, 46, 52, 53]
miR-322	T	Mouse	IRI	Down	[14]
miR-324-3p	T	Mouse	IRI	Down	[14]
miR-326	T	Mouse	IRI	Down	[34]
miR-328	T	Mouse	IRI	Down	[34]
miR-328a-3p	T, U	Rat	Cisplatin nephropathy	Up (urine),down (tissue)	[33]
miR-329	T, in vitro	Rat, CRL-2753 cells, NRK52E cells	UUO	Down	[45]
miR-335	T, U	Rat	Cisplatin nephropathy	Up (urine),down (tissue)	[33]
miR-340-5p	T, U	Rat	Cisplatin nephropathy	Up (urine),down (tissue)	[33]
miR-346	T	Mouse	IRI	Down	[34]
miR-362-5p	T	Mouse	IRI	Up	[14, 34]
miR-365*	In vitro	HK-2 cells, primary PTCs	AA nephropathy	Down	[38]
miR-378a-5p	T, U	Rat	Cisplatin nephropathy	Up (urine),down (tissue)	[33]
miR-379	T	Mouse	IRI	Down	[14, 49]
miR-382	In vitro	HK-2 cells, primary PTCs	AA nephropathy	Up	[38]
miR-423	U	Human	ICU and transplant AKI^a	Up	[29]
miR-449	In vitro	NRK-52E cells	Cisplatin nephropathy	Up	[67]
miR-450a-3p	T, in vitro	Mouse, HK-2 cells, primary PTCs	IRI, AA nephropathy	Up, down	[34, 38]
miR-451	T	Mouse	IRI	Up	[34]
miR-455-3p	T	Mouse	IRI	Down	[14]
miR-466a-5p	T	Mouse	IRI	Up	[34]
miR-466b-5p	T	Mouse	IRI	Up	[34]
miR-466c-5p	T	Mouse	IRI	Down	[34]
miR-466f-3p	T	Mouse	IRI	Down	[34]
miR-466g	T	Mouse	IRI	Down	[34]
miR-466i	T	Mouse	IRI	Down	[34]
miR-467	T	Mouse	IRI	Up	[14]
miR-467a	T	Mouse	IRI	Down	[34]
miR-467b	T	Mouse	IRI	Down	[34]
miR-467e	T	Mouse	IRI	Down	[34]
miR-467f	T	Mouse	IRI	Down	[34]
miR-467g	T	Mouse	IRI	Down	[34]
miR-468	T	Mouse	IRI	Down	[34]
miR-483	T	Mouse	IRI	Up, down?	[34]
miR-484	T	Mouse	IRI	Down	[34]
miR-486	T	Mouse	IRI	Up	[14]
miR-487b	T	Mouse	IRI	Down	[14]
miR-489	T	Mouse	IRI	Up	[14]
miR-491	T	Mouse	IRI	Down	[14]
miR-494	T, U, B	Mouse, human	IRI, ICU AKI^a	Up, unchanged	[48]
miR-495	T	Mouse	IRI	Up	[14]
miR-503	In vitro	HK-2 cells	ER stress	Down	[51]
miR-532-3p	T, U	Mouse, rat	IRI, Cisplatin nephropathy	Up, down	[33, 34]
miR-542-3p	In vitro	HK-2 cells, primary PTCs	AA nephropathy	Up	[38]
miR-547-3p	T	Mouse	IRI	Down	[34]
miR-574-5p	In vitro	HK-2 cells, primary PTCs	AA nephropathy	Down	[38]
miR-617	B	Human	ICU AKI^a	Up	[46]
miR-620	B	Human	ICU AKI^a	Down	[46]
miR-625*	In vitro	HK-2 cells, primary PTCs	AA nephropathy	Down	[38]
miR-630	In vitro	HK-2 cells	Oxidative stress	Up	[51]
miR-638	B	Human	ICU AKI^a	Up	[46]
miR-663b	B	Human	ICU AKI^a	Up	[46]
miR-668	T	Mouse	IRI	Up	[14]
miR-669a	T	Mouse	IRI	Down	[34]
miR-669f	T	Mouse	IRI	Down	[34]
miR-669h-3p	T	Mouse	IRI	Down	[34]
miR-671-3p	In vitro	HK-2 cells, primary PTCs	AA nephropathy	Down	[38]
miR-671-5p	T	Mouse	IRI	Up	[34]
miR-674	T	Mouse	IRI	Down	[34]
miR-680	T	Mouse	IRI	Up	[34]
miR-684	T	Mouse	IRI	Up	[34]
miR-685	T	Mouse	IRI	Up	[14, 34, 49]
miR-687	T, in vitro	Mouse, BUMPT-306 cells, HEK cells	IRI	Up	[14, 49]
miR-689	T	Mouse	IRI	Up	[34]
miR-694	T	Mouse	IRI	Up	[14]
miR-705	T	Mouse	IRI	Up	[34]
miR-708	T	Mouse	IRI	Up	[34]
miR-714	T, B	Mouse	IRI	Up	[68]
miR-718	T	Mouse	IRI	Down	[34]
miR-721	T	Mouse	IRI	Up	[34]
miR-744-5p	T, U	Rat	Cisplatin nephropathy	Up (urine),down (tissue)	[33]
miR-805	T, in vitro	Mouse, TECs	IRI	Down	[34, 37]
miR-875-5p	T	Mouse	IRI	Down	[34]
miR-876-5p	T	Mouse	IRI	Up	[34]
miR-877	T	Mouse	IRI	Up, down?	[34]
miR-877*	T, B	Mouse	IRI	Up	[68]
miR-1187	T	Mouse	IRI	Down	[34]
miR-1188	T, B	Mouse	IRI	Up	[68]
miR-1196	T	Mouse	IRI	Down	[34]
miR-1198	T	Mouse	IRI	Down	[34]
miR-1224	T, B	Mouse	IRI	Up	[68]
miR-1244	B	Human	ICU AKI^a	Down	[46]
miR-1249	In vitro	HK-2 cells, primary PTCs	AA nephropathy	Up	[38]
miR-1839-5p	T, U	Rat	Cisplatin nephropathy	Up (urine),down (tissue)	[33]
miR-1892	T	Mouse	IRI	Up	[34]
miR-1894-3p	T	Mouse	IRI	Up	[34]
miR-1897-3p	T, B	Mouse	IRI	Up	[68]
miR-4521	In vitro	HK-2 cells, primary PTCs	AA nephropathy	Down	[38]
miR-4640	U	Human	ICU and transplant AKI^a	Down	[29]
miR-4716-5p	In vitro	HK-2 cells, primary PTCs	AA nephropathy	Up	[38]
miR-4730	In vitro	HK-2 cells, primary PTCs	AA nephropathy	Up	[38]
miR-4747-3p	In vitro	HK-2 cells, primary PTCs	AA nephropathy	Up	[38]

^aHuman studies

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