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Table 1 miRNAs implicated in acute kidney injury

From: MicroRNAs in acute kidney injury

miRNA Samples Species Model Expression Reference
k12-3 In vitro HK-2 cells Oxidative stress Down then up [51]
let-7a T, B Rat, human Contrast nephropathy, contrast nephropathya Down [52]
let-7a-1-3p T, U Rat Cisplatin nephropathy Up (urine), down (tissue) [33]
let-7a-2* In vitro HK-2 cells, primary PTCs AA nephropathy Up [38]
let-7b B Human ICU AKIa Down [46]
let-7d U Rat Gentamicin nephropathy Down [53]
let-7e T, in vitro Mouse, HK-2 cells IRI Up, down [23, 54]
let-7f B, T Human, mouse ICU AKIa, IRI Down [34, 46]
let-7g T, U Mouse, rat Cisplatin nephropathy Up, down [33, 35]
miR-7 T, in vitro Mouse, HK-2 cells IRI, oxidative stress Up [14, 51]
miR-7a-1-3p T, U Rat Cisplatin nephropathy Up (urine), down (tissue) [33]
miR-10a T, U, B Mouse, human, rat IRI, DM-CKD (STZ), FSGSa, ICU AKIa Up, down [15, 16, 18]
miR-10b* T Mouse Cisplatin nephropathy Down [35]
miR-15 U Rat Cisplatin nephropathy Up [55]
miR-15b-5p T, in vitro Mouse, HK-2 cells IRI Down [54]
miR-16 B, U Human, rat ICU AKIa, cisplatin nephropathy Up, down [46, 55]
miR-17-3p T Mouse IRI Up [14, 49]
miR-17-5p T, U Mouse, rat IRI, cisplatin nephropathy Up, down [19, 20, 33]
miR-18a T, B, U, in vitro Mouse, rat, human, HPTECs IRI, gentamicin nephropathy, folic acid, CdCl2, arsenic trioxide, AA, K2Cr2O7, cisplatin, UUO, allograft rejectiona, renal fibrosisa Up, down [14, 34, 47, 56, 57]
miR-19a T Mouse IRI Up [34]
miR-20a T, in vitro, U Mouse, TECs, rat, HK-2 cells Cisplatin nephropathy, IRI Up, down [37, 54, 55]
miR-20b-5p T, U, in vitro Rat, mouse, HK-2 cells Cisplatin nephropathy, IRI Up (urine), down (tissue) [33, 54]
miR-21 B, U, T, in vitro Human, rat, mouse, TEC, CRL-2753 cells, NRK52E cells, HK-2 cells IRI, TGF-β, anti-Thy 1.1, UUO, SHRSP, gentamicin nephropathy, folic acid, CdCl2, arsenic trioxide, AA, K2Cr2O7, allograft rejectiona, renal fibrosisa, AKIa Up, down [1930, 34, 37, 45, 5658]
miR-24 B, T, in vitro Human, rat, CRL-2753 cells, NRK52E cells, HK-2 cells, HUVECs ICU AKIa, transplantationa, UUO, IRI Up, down [31, 45, 46]
miR-24-2 T Mouse IRI Up [34]
miR-25-3p T, U Rat Cisplatin nephropathy Up (urine), down (tissue) [33]
miR-26a In vitro, T HK-2 cells, mouse IRI, oxidative stress, cisplatin nephropathy Down [32, 35, 51]
miR-26b T, in vitro, U, B Rat, CRL-2753 cells, NRK52E cells, human UUO, cisplatin nephropathy, ICU AKIa Down (tissue, blood), up (urine) [18, 33, 45]
miR-27a-3p B Human ICU AKIa Down [18]
miR-29a T, in vitro, B HK-2 cells, human Oxidative stress, ICU AKIa Up, down [18, 51, 59]
miR-29b T, in vitro Rat, HK-2 cells Oxidative stress Up [51, 59]
miR-29c T Mouse IRI Up [34, 59]
miR-30a-5p T, U, in vitro, B Rat, mouse, HK-2 cells, human Cisplatin nephropathy, IRI, contrast-induced nephropathy, contrast-induced nephropathya Up (urine, blood, tissue), down (tissue) [33, 52, 54]
miR-30c T, in vitro, B Rat, CRL-2753 cells, NRK52E cells, mouse, human TGF-β, UUO, SHRSP, contrast-induced nephropathy, contrast-induced nephropathya Up, down [34, 45, 52]
miR-30c-1 T Mouse IRI Up [34]
miR-30c-2* In vitro HK-2 cells Oxidative stress Down [51]
miR-30d T, U, B Mouse, human IRI, DM-CKD (STZ), FSGSa Up, down, unchanged [16]
miR-30d* B Human ICU AKIa Down [46]
miR-30e T, B Mouse, rat, human Cisplatin nephropathy, contrast-induced nephropathy, contrast-induced nephropathya Up, down [35, 52]
miR-34a T, in vitro Mouse, BUMPT-306 cells, NRK-52E cells, RTECs Cisplatin nephropathy, IRI Up [35, 60, 61]
miR-34b T Mouse IRI Up [47]
miR-92a T Mouse IRI Up [34]
miR-92b* B Human ICU AKIa Up [46]
miR-93-3p B Human ICU AKIa, AKI post-cardiac surgerya Down [18]
miR-93-5p T, U Rat Cisplatin nephropathy Up (urine), down (tissue) [33]
miR-99b In vitro, T HK-2 cells, mouse ER stress, IRI Down [51, 54]
miR-101-3p B Human ICU AKIa Down [18]
miR-101a T, in vitro Mouse, HK-2 cells UUO Down [25]
miR-106a-5p T, in vitro Mouse, HK-2 cells, primary PTCs, rat IRI, AA nephropathy Up, down [19, 20, 38]
miR-122 T Mouse Cisplatin nephropathy, IRI Down [35, 49]
miR-123 T Mouse IRI Up [49]
miR-125a-5p T, in vitro Mouse, HK-2 cells IRI Down [54]
miR-125b T, in vitro Mouse, HepG2 cells, HEK293 cells, NRK52E cells Cisplatin nephropathy   [62]
miR-126-3p B Human ICU AKIa Down [18]
miR-126-5p T, in vitro Mouse, rat, TEnCs, TEpCs IRI Up [34, 43, 44, 63]
miR-127-3p T, in vitro, B Rat, mouse, NRK-52E cells, HK-2 cells, human IRI, ICU AKIa, AKI post-cardiac surgerya Up, down [14, 18, 36, 49]
miR-129-3p T Mouse IRI Up [34]
miR-129-5p In vitro HK-2 cells, primary PTCs AA nephropathy Down [38]
miR-130b-3p T, U Rat Cisplatin nephropathy Up (urine), down (tissue) [33]
miR-132 T, in vitro Mouse, human, HPTECs IRI, folic acid, CdCl2, arsenic trioxide, AA, K2Cr2O7, cisplatin, UUO, allograft rejectiona, renal fibrosisa Up [14, 57]
miR-133a In vitro HK-2 cells ER stress Down [51]
miR-134 T Mouse IRI Up [47]
miR-135b T Mouse IRI Down [14, 49]
miR-140-3p T, U Rat Cisplatin nephropathy Up (urine), down (tissue) [33]
miR-141 T Mouse IRI Up [34]
miR-142-3p T, in vitro Mouse, HK-2 cells UUO Up [25]
miR-142-5p T, in vitro Mouse, HK-2 cells UUO Up [25]
miR-145 T, in vitro Rat, mouse, CRL-2753 cells, NRK52E cells, CD133+ renal medullary progenitor cells TGF-β, SHRSP salt challenge Up, down [39, 45, 64]
miR-146a T, in vitro, B Mouse, TECs, human IRI, ICU AKIa Down (blood), up (tissue) [18, 37]
miR-146b-5p T, in vitro Mouse, human, HPTECs IRI, folic acid, CdCl2, arsenic trioxide, AA, K2Cr2O7, cisplatin, UUO, allograft rejectiona, renal fibrosisa Up [57]
miR-149 T Mouse IRI Down [34]
miR-150 T, in vitro Mouse, immortalized mouse cardiac endothelial cell lines IRI, AMI using LAD ligation Down [65]
miR-155 B, U, T, in vitro Rat, human, mouse, HK-2 cells IRI, gentamicin nephropathy, Cisplatin nephropathy, AKIa Up, down [54, 56, 66]
miR-181a* In vitro HK-2 cells ER stress Up [51]
miR-181a-2* In vitro HK-2 cells ER stress Down [51]
miR-181d T Mouse IRI Down [34]
miR-182 T Mouse IRI Up [47]
miR-183-5p T, U Rat Cisplatin nephropathy Up (urine), down (tissue) [33]
miR-187 T, in vitro Mouse, TECs IRI Down [37]
miR-188-5p T Mouse IRI Up [34]
miR-191a-5p T, U Rat Cisplatin nephropathy Up (urine), down (tissue) [33]
miR-192 T, in vitro, B, U Mouse, rat, CRL-2753 cells, NRK52E cells, TECs, HK-2 cells, primary PTCs IRI, UUO, SHRSP, AA nephropathy, cisplatin nephropathy, contact freezing, Dahl salt-sensitive rat with high salt administration Up, down [15, 33, 45, 55]
miR-193 T, in vitro, U Mouse, HK-2 cells, Rat UUO, cisplatin nephropathy Down (tissue), up (urine) [25, 33, 35, 55]
miR-194 T, in vitro, B, U Mouse, rat, TECs, HK-2 cells, primary PTCs IRI, AA nephropathy, contact freezing, Dahl salt-sensitive rat with high salt administration Up, down [15, 3739]
miR-197 T Mouse IRI Down [34]
miR-199a-3p T, in vitro Mouse, TECs IRI Up [37]
miR-200a T, B, U Human, Rat, mouse Contact freezing, Dahl salt-sensitive rat with high salt administration, contrast-induced nephropathy, contrast-induced nephropathya Up, down [39, 52]
miR-200b T, in vitro, B, U Rat, CRL-2753 cells, NRK52E cells, human TGF-β, UUO, contact freezing, early CKD (Dahl salt-sensitive rat with high salt administration) Up, down [34, 39, 45]
miR-200c T, in vitro, U, B Rat, CRL-2753 cells, NRK52E cells, human TGF-β, contact freezing, early CKD (Dahl salt-sensitive rat with high salt administration), ICU and transplant AKIa Up, down [29, 39, 45]
miR-202 In vitro HK-2 cells ER stress Down [51]
miR-203 U Rat Gentamicin nephropathy Down [53]
miR-205 In vitro HK-2 cells, primary PTCs Oxidative stress, ER stress, AA nephropathy Down [38, 51]
miR-207 T Mouse IRI Up, down [14, 34]
miR-210 B, T, in vitro, U Human, mouse, HUVEC-12 cells, HK-2 cells, primary PTCs, rat IRI, Oxidative stress, AA nephropathy, cisplatin nephropathy, ICU AKIa Up, down [18, 34, 38, 46, 47, 51, 55]
miR-211 T Mouse IRI Down [34]
miR-212 T Mouse, human, HPTECs IRI, folic acid, CdCl2, arsenic trioxide, AA, K2Cr2O7, cisplatin, UUO, allograft rejectiona, renal fibrosisa Up, down [34, 57]
miR-214 T, in vitro Mouse, rat, HK-2 cells, TECs, CRL-2753 cells, NRK52E cells, human TGF-β, anti-Thy 1.1, UUO, SHRSP, IRI, diabetic nephropathya Up [2325, 37, 45, 47]
miR-215 In vitro HK-2 cell ER stress Down [51]
miR-218 T, in vitro Mouse, HK-2 cells UUO Down [25]
miR-218-1 T Mouse IRI Up [34]
miR-218a-5p T, U Rat Cisplatin nephropathy Up (urine),down (tissue) [33]
miR-221* In vitro HK-2 cells Oxidative stress Up [51]
miR-223 T, in vitro Mouse, HK-2 cells UUO Up [25]
miR-290-3p T Mouse IRI Up [34]
miR-296 T, in vitro Rat, mouse, TEnCs, TEpCs IRI Up, down [14, 43]
miR-302b T Mouse IRI Up [34]
miR-302c T Mouse IRI Up [34]
miR-320 B, T, U Human, mouse, rat IRI, cisplatin nephropathy, gentamicin nephropathy, contrast-induced nephropathy, ICU AKIa, contrast-induced nephropathya Up, down [23, 33, 34, 46, 52, 53]
miR-322 T Mouse IRI Down [14]
miR-324-3p T Mouse IRI Down [14]
miR-326 T Mouse IRI Down [34]
miR-328 T Mouse IRI Down [34]
miR-328a-3p T, U Rat Cisplatin nephropathy Up (urine),down (tissue) [33]
miR-329 T, in vitro Rat, CRL-2753 cells, NRK52E cells UUO Down [45]
miR-335 T, U Rat Cisplatin nephropathy Up (urine),down (tissue) [33]
miR-340-5p T, U Rat Cisplatin nephropathy Up (urine),down (tissue) [33]
miR-346 T Mouse IRI Down [34]
miR-362-5p T Mouse IRI Up [14, 34]
miR-365* In vitro HK-2 cells, primary PTCs AA nephropathy Down [38]
miR-378a-5p T, U Rat Cisplatin nephropathy Up (urine),down (tissue) [33]
miR-379 T Mouse IRI Down [14, 49]
miR-382 In vitro HK-2 cells, primary PTCs AA nephropathy Up [38]
miR-423 U Human ICU and transplant AKIa Up [29]
miR-449 In vitro NRK-52E cells Cisplatin nephropathy Up [67]
miR-450a-3p T, in vitro Mouse, HK-2 cells, primary PTCs IRI, AA nephropathy Up, down [34, 38]
miR-451 T Mouse IRI Up [34]
miR-455-3p T Mouse IRI Down [14]
miR-466a-5p T Mouse IRI Up [34]
miR-466b-5p T Mouse IRI Up [34]
miR-466c-5p T Mouse IRI Down [34]
miR-466f-3p T Mouse IRI Down [34]
miR-466g T Mouse IRI Down [34]
miR-466i T Mouse IRI Down [34]
miR-467 T Mouse IRI Up [14]
miR-467a T Mouse IRI Down [34]
miR-467b T Mouse IRI Down [34]
miR-467e T Mouse IRI Down [34]
miR-467f T Mouse IRI Down [34]
miR-467g T Mouse IRI Down [34]
miR-468 T Mouse IRI Down [34]
miR-483 T Mouse IRI Up, down? [34]
miR-484 T Mouse IRI Down [34]
miR-486 T Mouse IRI Up [14]
miR-487b T Mouse IRI Down [14]
miR-489 T Mouse IRI Up [14]
miR-491 T Mouse IRI Down [14]
miR-494 T, U, B Mouse, human IRI, ICU AKIa Up, unchanged [48]
miR-495 T Mouse IRI Up [14]
miR-503 In vitro HK-2 cells ER stress Down [51]
miR-532-3p T, U Mouse, rat IRI, Cisplatin nephropathy Up, down [33, 34]
miR-542-3p In vitro HK-2 cells, primary PTCs AA nephropathy Up [38]
miR-547-3p T Mouse IRI Down [34]
miR-574-5p In vitro HK-2 cells, primary PTCs AA nephropathy Down [38]
miR-617 B Human ICU AKIa Up [46]
miR-620 B Human ICU AKIa Down [46]
miR-625* In vitro HK-2 cells, primary PTCs AA nephropathy Down [38]
miR-630 In vitro HK-2 cells Oxidative stress Up [51]
miR-638 B Human ICU AKIa Up [46]
miR-663b B Human ICU AKIa Up [46]
miR-668 T Mouse IRI Up [14]
miR-669a T Mouse IRI Down [34]
miR-669f T Mouse IRI Down [34]
miR-669h-3p T Mouse IRI Down [34]
miR-671-3p In vitro HK-2 cells, primary PTCs AA nephropathy Down [38]
miR-671-5p T Mouse IRI Up [34]
miR-674 T Mouse IRI Down [34]
miR-680 T Mouse IRI Up [34]
miR-684 T Mouse IRI Up [34]
miR-685 T Mouse IRI Up [14, 34, 49]
miR-687 T, in vitro Mouse, BUMPT-306 cells, HEK cells IRI Up [14, 49]
miR-689 T Mouse IRI Up [34]
miR-694 T Mouse IRI Up [14]
miR-705 T Mouse IRI Up [34]
miR-708 T Mouse IRI Up [34]
miR-714 T, B Mouse IRI Up [68]
miR-718 T Mouse IRI Down [34]
miR-721 T Mouse IRI Up [34]
miR-744-5p T, U Rat Cisplatin nephropathy Up (urine),down (tissue) [33]
miR-805 T, in vitro Mouse, TECs IRI Down [34, 37]
miR-875-5p T Mouse IRI Down [34]
miR-876-5p T Mouse IRI Up [34]
miR-877 T Mouse IRI Up, down? [34]
miR-877* T, B Mouse IRI Up [68]
miR-1187 T Mouse IRI Down [34]
miR-1188 T, B Mouse IRI Up [68]
miR-1196 T Mouse IRI Down [34]
miR-1198 T Mouse IRI Down [34]
miR-1224 T, B Mouse IRI Up [68]
miR-1244 B Human ICU AKIa Down [46]
miR-1249 In vitro HK-2 cells, primary PTCs AA nephropathy Up [38]
miR-1839-5p T, U Rat Cisplatin nephropathy Up (urine),down (tissue) [33]
miR-1892 T Mouse IRI Up [34]
miR-1894-3p T Mouse IRI Up [34]
miR-1897-3p T, B Mouse IRI Up [68]
miR-4521 In vitro HK-2 cells, primary PTCs AA nephropathy Down [38]
miR-4640 U Human ICU and transplant AKIa Down [29]
miR-4716-5p In vitro HK-2 cells, primary PTCs AA nephropathy Up [38]
miR-4730 In vitro HK-2 cells, primary PTCs AA nephropathy Up [38]
miR-4747-3p In vitro HK-2 cells, primary PTCs AA nephropathy Up [38]
  1. aHuman studies