From: Major influence of repetitive elements on disease-associated copy number variants (CNVs)
 | Retrotransposons (interspersed repeats)—44 % human genome | ||
---|---|---|---|
Non-long terminal repeat (LTR) | Long terminal repeat (LTR) | ||
Repetitive element | Long interspersed nuclear repeats (LINEs) | Short interspersed nuclear repeats (SINEs) | Endogenous retroviruses (ERV) |
Genomic coverage | 20Â % | 11Â % | 8Â % |
Features | • L1 is the most abundant class • Autonomous transposons • Reverse transcriptase (RT) encoded by LINE-1 | • Alu is the most abundant class • Dependent on LINEs transposable machinery • Mobile polymerase III promoter • 100–400 bp in length | • Reduced transposable activity • Presence of gag and pol viral genes |