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Fig. 2 | Human Genomics

Fig. 2

From: Head-and-neck squamous cell carcinoma risk in smokers: no association detected between phenotype and AHR, CYP1A1, CYP1A2, or CYP1B1 genotype

Fig. 2

LD heat map of CYP1B1 SNPs from the entire cohort (N = 211), using r 2 (correlation between pair of loci) as a measure of LD. Haploblock 2—which we had found initially as apparently the only haplotype (ACTTGATC) significantly associated with HNSCC risk in smokers—contains two SNPs in the 5′ half of exon 2 plus six SNPs in the 5′-flanking region (reverse strand), extending as far 5′-ward as 4538 bp upstream of the transcription initiation start-site. Shading denotes the following: white (r 2 = 0), black (r 2 = 1), and shades of gray (0 < r 2 < 1), with deepening gray colors depicting increasing r 2 values (correlation) between SNP pairs. Numbers in each square indicate percentage of correlation (r 2 × 100).

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