Fig. 11
From: Transcriptome analysis reveals manifold mechanisms of cyst development in ADPKD
Immune response is abnormal in ADPKD. NC-ADPKD and C-ADPKD cells both express higher-than-normal levels of genes from ‘immune response’ gene sets, exception that C-ADPKD cells have lower-than-normal expression of the KEGG ‘Complement and Coagulation cascade’ gene set (12). We present data as mean ± s.e.m., **P < 0.01, *P < 0.05 (black asterisk is in comparison to NK, gray asterisk is in comparison to NC-ADPKD). Immune Response Gene Sets: (1) INFLAMMATORY_RESPONSE, (2) IMMUNE_RESPONSE, (3) HUMORAL_IMMUNE_RESPONSE, (4) CELL_ACTIVATION, (5) IMMUNE_SYSTEM_PROCESS, (6) LEUKOCYTE_ACTIVATION, (7) LYMPHOCYTE_ACTIVATION, (8) KEGG_CHEMOKINE_SIGNALING_PATHWAY, (9) KEGG_NOD_LIKE_RECEPTOR_SIGNALING_PATHWAY, (10) KEGG_T_CELL_RECEPTOR_SIGNALING_PATHWAY, (11) KEGG_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION, (12) KEGG_COMPLEMENT_AND_COAGULATION_CASCADES, (13) KEGG_CYTOSOLIC_DNA_SENSING_PATHWAY, (14) KEGG_HEMATOPOIETIC_CELL_LINEAGE, (15) KEGG_FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS