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Fig. 14 | Human Genomics

Fig. 14

From: Transcriptome analysis reveals manifold mechanisms of cyst development in ADPKD

Fig. 14

ADPKD broadly perturbs metabolism. a Cofactor and vitamin, amino acid, and energy metabolism and b carbohydrate, drug, lipid, and glycan metabolism. C-ADPKD cells have lower-than-normal expression of genes in ‘cofactor and vitamin’ gene sets (A1-2) compared to both NK and NC-ADPKD cells. Both NC-ADPKD and C-ADPKD cells have lower-than-normal expression of genes in ‘amino acid’ gene sets (A3-11). C-ADPKD cells have lower-than-normal expression of genes in ‘energy metabolism’ gene sets (A12-14). C-ADPKD cells have lower-than-normal expression of genes in all ‘carbohydrate metabolism’ gene sets (B1-9) except for the KEGG ‘histidine metabolism’ gene set. C-ADPKD cells have lower-than-normal expression of genes in the ‘drug metabolism’ gene set (B10). C-ADPKD cells have lower-than-normal expression of genes in all ‘lipid metabolism’ (B11-18) gene sets except for the KEGG ‘arachidonic acid metabolism’ gene set (B13). C-ADPKD cells have lower-than-normal expression of genes in ‘glycan metabolism’ gene sets (B19-20). We present data as mean ± s.e.m., **P < 0.01, *P < 0.05 (black asterisk is in comparison to NK, gray asterisk is in comparison to NC-ADPKD). a Cofactor and vitamin, amino acid, and energy metabolism gene sets. Cofactor and Vitamin Gene Sets: (1) KEGG_RETINOL_METABOLISM, (2) KEGG_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM. Amino Acid Metabolism Gene Sets: (3) KEGG_ALANINE_ASPARTATE_AND_GLUTAMATE_METABOLISM, (4) KEGG_GLYCINE_SERINE_AND_THREONINE_METABOLISM, (5) KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION, (6) KEGG_ARGININE_AND_PROLINE_METABOLISM, (7) KEGG_HISTIDINE_METABOLISM, (8) KEGG_TRYPTOPHAN_METABOLISM, (9) KEGG_BETA_ALANINE_METABOLISM, (10) KEGG_SELENOAMINO_ACID_METABOLISM, (11) KEGG_GLUTATHIONE_METABOLISM. Energy Metabolism Gene Sets: (12) KEGG_OXIDATIVE_PHOSPHORYLATION, (13) MITOCHONDRIAL_TRANSPORT, (14) MITOCHONDRION_ORGANIZATION_AND_BIOGENESIS. b Carbohydrate, drug, lipid and glycan metabolism gene sets. Carbohydrate Metabolism Gene Sets: (1) KEGG_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM, (2) KEGG_PROPANOATE_METABOLISM, (3) KEGG_BUTANOATE_METABOLISM (4) KEGG_GLYCOLYSIS_GLUCONEOGENESIS, (5) KEGG_CITRATE_CYCLE_TCA_CYCLE, (6) KEGG_PYRUVATE_METABOLISM, (7) KEGG_FRUCTOSE_AND_MANNOSE_METABOLISM, (8) KEGG_GALACTOSE_METABOLISM, (9) KEGG_AMINO_SUGAR_AND_NUCLEOTIDE_SUGAR_METABOLISM. Drug Metabolism Gene Sets; (10) KEGG_DRUG_METABOLISM_CYTOCHROME_P450. Lipid Metabolism Gene Sets: (11) KEGG_GLYCEROLIPID_METABOLISM, (12) KEGG_GLYCEROPHOSPHOLIPID_METABOLISM, (13) KEGG_ARACHIDONIC_ACID_METABOLISM, (14) KEGG_LINOLEIC_ACID_METABOLISM, (15) KEGG_SPHINGOLIPID_METABOLISM, (16) KEGG_FATTY_ACID_METABOLISM, (17) KEGG_STEROID_HORMONE_BIOSYNTHESIS, (18) PHOSPHOLIPID_BIOSYNTHETIC_PROCESS. Glycan Metabolism Gene Sets: (19) KEGG_N_GLYCAN_BIOSYNTHESIS, (20) KEGG_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI_ANCHOR_BIOSYNTHESIS

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