Transcriptome analysis reveals manifold mechanisms of cyst development in ADPKD

Table 1 GSEA analysis summary

GSEA summary for NC-ADPKD/NK
Upregulated in		# gene sets	FDR < 0.25	FDR < 0.05	P < 0.05	P < 0.01
NK	KEGG	162	15	5	11	7
NK	GOBP	467	0	0	6	1
NC-ADPKD	KEGG	162	0	0	20	3
NC-ADPKD	GOBP	467	10	0	41	18
GSEA summary for C-ADPKD/NK
Upregulated in		# gene sets	FDR < 0.25	FDR < 0.05	P < 0.05	P < 0.01
NK	KEGG	162	2	0	8	0
NK	GOBP	467	0	0	11	2
C-ADPKD	KEGG	162	15	3	17	12
C-ADPKD	GOBP	467	1	1	46	13
GSEA summary for NC-ADPKD/C-ADPKD
Upregulated in		# gene sets	FDR < 0.25	FDR < 0.05	P < 0.05	P < 0.01
NC-ADPKD	KEGG	162	11	0	10	4
NC-ADPKD	GOBP	467	17	0	24	13
C-ADPKD	KEGG	162	11	4	18	10
C-ADPKD	GOBP	467	3	1	42	15

Numbers of gene sets that reach significance in comparisons of two GSEA classes, FDR < 0.05, are bold. FDR false discovery rate, P nominal P value, as described by Subramanian et al. 2005 [26]. GSEA expresses all differences as upregulation to minimize class bias due to the intrinsic asymmetry of the method

ISSN: 1479-7364