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Table 2 KEGG pathways and GO terms identified as differentially expressed by GSEA analysis

From: Transcriptome analysis reveals manifold mechanisms of cyst development in ADPKD

 

Size

ES

NES

Normal P value

FDR

FWER P value

NC-ADPKD/NK, upregulated in NK

 KEGG_drug_metabolism_cytochrome_p450

42

0.8

2.17

0

0

0

 KEGG_metabolism_of xenobiotics_by_cytochrome p450

42

0.7

2.06

0

0

0.001

 KEGG_histidine_metabolism

22

0.8

1.94

0

0.006

0.019

 KEGG_glutathione_metabolism

38

0.7

1.86

0

0.013

0.049

 KEGG_fatty_acid_metabolism

32

0.6

1.73

0.004

0.048

0.209

C-ADPKD/NK, upregulated in C-ADPKD

 KEGG_chemokine_signaling_pathway

144

−1

−1.73

0

0.01

0.011

 KEGG_axon_guidance

99

−1

−1.68

0

0.03

0.066

 KEGG_leukocyte_transendothelial_migration

86

−1

−1.66

0.001

0.028

0.092

 GOBP_cell_cell_adhesion

48

0.8

1.8

0

0.001

0.001

NC-ADPKD/C-ADPKD, upregulated in C-ADPKD

 KEGG_leukocyte_transendothelial_migration

86

−1

−1.82

0

0

0

 KEGG_chemokine_signaling_pathway

144

−1

−1.74

0

0.024

0.05

 KEGG_tight_junction

101

−1

−1.73

0

0.02

0.063

 KEGG_axon_guidance

99

−1

−1.73

0

0.016

0.066

 GOBP_cell_cell_adhesion

48

0.8

1.8

0

0.007

0.008

  1. Listing of KEGG pathways and GO terms with FDR < 5 %. GSEA expresses all differences as upregulation to minimize class bias due to the intrinsic asymmetry of the method