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Table 1 Association of variants at 11q23.3 chromosomal region with anatomical categories of CAD

From: Genetic determinants of clinical heterogeneity of the coronary artery disease in the population of Hyderabad, India

SNP (major/minor allele)

Nearby/associated gene

MAF in Controls Nā€‰=ā€‰462

Insignificant (nā€‰=ā€‰93)

Single vessel disease (nā€‰=ā€‰121)

Double vessel disease (nā€‰=ā€‰75)

Triple vessel disease (nā€‰=ā€‰70)

MAF

p value

OR (95% CI)

MAF

p value

OR (95% CI)

MAF

p value

OR (95% CI)

MAF

p value

OR (95% CI)

rs17440396:G>A

BUD13

0.21

0.02

3.5ā€‰Ć—ā€‰10āˆ’10

0.06 (0.02ā€“0.20)

0.03

1.3ā€‰Ć—ā€‰10āˆ’10

0.13 (0.06ā€“0.27)

0.03

2.3ā€‰Ć—ā€‰10āˆ’07

0.13 (0.05ā€“0.32)

0.04

2.1ā€‰Ć—ā€‰10āˆ’06

0.15 (0.06ā€“0.37)

rs10488699:G>A

0.20

0.26

0.040

1.47 (1.02ā€“2.13)

Ā Ā Ā Ā Ā Ā 

0.27

0.042

1.55 (1.01ā€“2.35)

rs664059:C>T

0.30

Ā Ā Ā 

0.38

0.017

1.43 (1.06ā€“1.92)

Ā Ā Ā 

0.39

0.042

1.47 (1.01ā€“2.13)

rs6589566:A>G

ZPR1

0.25

0.43

1.5ā€‰Ć—ā€‰10āˆ’06

2.25 (1.61ā€“3.14)

0.37

0.0005

1.71 (1.26ā€“2.33)

0.42

1.9ā€‰Ć—ā€‰10āˆ’05

2.18 (1.52ā€“3.13)

0.39

0.002

1.86 (1.25ā€“2.76)

rs3741298:A>G

0.35

0.27

0.038

0.68 (0.48ā€“0.98)

Ā Ā Ā Ā Ā Ā Ā Ā Ā 

rs2075294:G>T

0.05

Ā Ā Ā 

0.10

0.012

1.93 (1.15ā€“3.24)

Ā Ā Ā 

0.09

0.048

1.89 (1.00ā€“3.59)

rs633389:C>T

APOA5-APOA4

0.16

0.08

0.004

0.44 (0.25ā€“0.78)

0.10

0.033

0.62 (0.39ā€“0.97)

0.07

0.003

0.38 (0.19ā€“0.73)

0.07

0.005

0.38 (0.19ā€“0.76)

rs633867:C>T

0.06

Ā Ā Ā 

0.10

0.020

1.81 (1.09ā€“2.99)

Ā Ā Ā Ā Ā Ā 

rs11600380:T>C

0.31

Ā Ā Ā Ā Ā Ā Ā Ā Ā 

0.22

0.030

0.62 (0.41ā€“0.96)

rs1263163:G>A

0.21

Ā Ā Ā Ā Ā Ā 

0.11

0.009

0.50 (0.30ā€“0.85)

0.10

0.004

0.44 (0.25ā€“0.78)

rs625524:G>A

0.05

0.10

0.006

2.21 (1.24ā€“3.92)

Ā Ā Ā Ā Ā Ā 

0.01

0.028

0.15 (0.02ā€“1.07)

rs1263171:G>A

0.43

Ā Ā Ā Ā Ā Ā 

0.53

0.029

1.47 (1.04ā€“2.08)

0.55

0.008

1.62 (1.13ā€“2.32)

rs2727793:G>A

0.37

Ā Ā Ā Ā Ā Ā 

0.45

0.044

1.43 (1.01ā€“2.02)

Ā Ā Ā 

rs7396835:C>T

0.44

Ā Ā Ā Ā Ā Ā 

0.35

0.042

0.69 (0.48ā€“0.99)

Ā Ā Ā 

rs2542063:G>A

0.37

Ā Ā Ā Ā Ā Ā 

0.45

0.047

1.43 (1.00ā€“2.02)

Ā Ā Ā 

rs2849165:G>A

0.36

0.20

3.1ā€‰Ć—ā€‰10āˆ’05

0.45 (0.31ā€“0.66)

0.22

2.9ā€‰Ć—ā€‰10āˆ’05

0.49 (0.35ā€“0.69)

0.21

0.0002

0.47 (0.31ā€“0.71)

0.23

0.004

0.54 (0.35ā€“0.83)

rs5081:A>T

APOA1

0.03

Ā Ā Ā 

0.07

0.008

2.25 (1.22ā€“4.16)

Ā Ā Ā Ā Ā Ā 

rs5072:C>T

0.37

Ā Ā Ā 

0.30

0.037

0.72 (0.53ā€“0.98)

Ā Ā Ā Ā Ā Ā 

rs632153:G>T

0.03

Ā Ā Ā 

0.06

0.020

2.11 (1.11ā€“4.02)

Ā Ā Ā Ā Ā Ā 
  1. Italic fontā€”significant after Benjamin Hochberg Correction, blank cellā€”not significant
  2. MAF minor allele frequency, OR odds ratio obtained from logistic regression analysis