| ClinvarHC | Humsavar | Swissvar | Varibench | TP53-TA | BRCA1-DMS | UniFun | |||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
 | AUC | MCC | AUC | MCC | AUC | MCC | AUC | MCC | AUC | MCC | AUC | MCC | AUC | MCC |
GERP++ | 0.863 | 0.587 | 0.777 | 0.469 | 0.677 | 0.286 | 0.571 | 0.15 | 0.719 | 0.283 | 0.544 | 0.069 | 0.538 | 0.04 |
fitCons | 0.641 | 0.3 | 0.533 | 0.033 | 0.564 | 0.008 | 0.651 | 0.024 | 0.557 | 0 | 0.559 | 0 | 0.515 | 0.033 |
SIFT | 0.848 | 0.489 | 0.841 | 0.543 | 0.698 | 0.289 | 0.651 | 0.228 | 0.835 | 0.484 | 0.653 | 0.199 | 0.631 | 0.184 |
PolyPhen | 0.827 | 0.447 | 0.831 | 0.541 | 0.699 | 0.301 | 0.672 | 0.256 | 0.859 | 0.469 | 0.596 | 0.088 | 0.623 | 0.168 |
CADD | 0.939 | 0.731 | 0.851 | 0.57 | 0.73 | 0.331 | 0.663 | 0.25 | 0.869 | 0.418 | 0.556 | 0.032 | 0.589 | 0.119 |
Condel | 0.879 | 0.51 | 0.911 | 0.664 | 0.728 | 0.333 | 0.86 | 0.57 | 0.883 | 0.074 | 0.747 | 0.172 | 0.614 | 0.098 |
REVEL | 0.945 | 0.68 | 0.968 | 0.83 | 0.792 | 0.462 | 0.89 | 0.59 | 0.907 | 0.465 | 0.737 | 0.088 | 0.63 | 0.148 |
fathmm | 0.787 | 0.288 | 0.902 | 0.538 | 0.701 | 0.253 | 0.936 | 0.509 | 0.53 | 0 | 0.621 | 0 | 0.531 | 0.02 |