Table 1 Frequency of somatic NF1 mutations in different human neoplasms

Cutaneous melanoma

12–30%

[49,50,51, 58]

Desmoplastic melanoma

45–90%

[60, 61]

Lung adenocarcinoma

7–11.8%

[65,66,67, 166, 176, 177]

Lung squamous cell carcinoma

10.3–11%

[72, 177]

Acute myeloid leukaemia

3.5–23.6%

[82,83,84,85]

T cell acute lymphoblastic leukaemia

3%

[88]

Breast cancer

2.5–27.7%

[106, 177]

Ovarian carcinoma

12–34.4%

[113, 115, 170, 177,178,179,180]

Paraganglioma/phaeochromocytoma

21–26%

[121, 124, 177]

Neuroblastoma

2.2–6%

[130]

Glioblastoma

14–23%

[132, 134, 177]

Colon adenocarcinoma

3.8–6.25%

[143, 177]

Bladder transitional cell carcinoma

6–14%

[149, 167, 177]