Table 1 lncRNAs associated with β cell function and type 1 diabetes
From: Long non-coding RNAs as novel players in β cell function and type 1 diabetes
lncRNAs | Function | Reference |
|---|---|---|
MEG3 | Regulates β cell identity and function via insulin production and apoptosis in mouse MIN6 cells and isolated mouse islets | You et al. 2016 [22] |
HI-LNC25 | Positively regulates GLIS3 (which contains both T1D and T2D risk variants) in EndoC-βH1 human β cell line | Moran et al. 2012 [18] |
βlinc1 (HI-LNC15) | Regulates β cell identity and function in mouse MIN6 cells and EndoC-βH1 human β cell line; also regulates its neighboring gene NKX2.2 (an islet transcription factor). | Arnes et al. 2016 [23] |
TUNAR (HI-LNC78) | Knockdown of TUNAR leads to impaired glucose-stimulated insulin secretion in human islets | Akerman et al. 2017 [24] |
PLUT (HI-LNC71) | Regulates transcription of PDX1, a key pancreatic β cell transcriptional regulator, in EndoC-βH1 cells, primary islet cells, mouse β cell line MIN6 | Akerman et al. 2017 [24] |
MALAT1 | Upregulation of MALAT1 is associated with microvascular dysfunction (diabetic retinopathy) in STZ-induced diabetic rats and db/db mice | Liu et al. 2014 [20] |
TUG1 | Downregulation of lncRNA TUG1 expression increased apoptosis and reduced insulin secretion in mouse β cells | Yin et al. 2015 [25] |