Distinct transcriptional and metabolic profiles associated with empathy in Buddhist priests: a pilot study

Table 1 Up-expressed genes in the priests

Up genes	Enterz Gene ID	Gene name	Fold change	P value	FDR	Average raw
MX1	4599	MX dyn amin-like GTPase 1	2.00	5.7E − 05	0.0352	4503
IFI27	3429	Interferon-α-inducible protein 27	2.60	9.9E − 08	0.0003	1990
MYOM2	9172	Myomesin 2	1.84	6.6E − 08	0.0003	1957
IFIT3	3437	Interferon-induced protein with tetratricopeptide repeats 3	1.77	7.7E − 05	0.0410	1890
IFIT1	3434	Interferon-induced protein with tetratricopeptide repeats 1	2.20	5.8E − 06	0.0073	1682
RSAD2	91,543	Radical S-adenosyl methionine domain containing 2	2.99	< E − 09	0.0000	1347
FOLR3	2352	Folate receptor 3 (γ)	1.82	1.3E − 05	0.0129	1079
BTNL3	10,917	Butyrophilin-like 3	2.23	< E − 09	0.0000	880
DEFA4	1669	Defensin, α4, Corticostatin	2.09	2.1E − 06	0.0034	824
IFI44L	10,964	Interferon-induced protein 44-like	2.58	2.0E − 07	0.0005	726
BATF2	116,071	Basic leucine zipper transcription factor, ATF-like 2	1.54	8.7E − 05	0.0448	540
C4BPA	722	Complement component 4 binding protein, α	2.14	6.6E − 08	0.0003	353
CTSG	1511	Cathepsin G	1.73	7.2E − 05	0.0395	301
HERC5	51,191	HECT and RLD domain containing E3 ubiquitin protein ligase 5	2.05	2.0E − 05	0.0174	266
S100B	6285	S100 calcium binding protein B	1.52	4.5E − 05	0.0305	195
ARPC5	10,092	Actin related protein 2/3 complex, subunit 5, 16 kDa	1.66	2.4E − 05	0.0193	120
LOC 728715	728,715	Ovostatin homolog 2-like	2.75	3.3E − 07	0.0008	72
LOC 100509445	100,509,445	Uncharacterized LOC100509445	4.29	< E − 09	0.0000	67

Representative list of genes up-expressed (> 1.5-fold) in priests compared to the controls. The described data is in descending ordered of the average raw signals (> 50) in the priests’ group microarray data. MX1, IFI27, IFIT1, IFIT3, RSAD2, IFI44L, and HERC5 have been validated by quantitative real-time PCR (Fig. 1)

ISSN: 1479-7364