Distinct transcriptional and metabolic profiles associated with empathy in Buddhist priests: a pilot study

Table 2 Down-expressed genes in the priests

Down genes	Enterz Gene ID	Gene name	Fold change	P value	FDR	Average raw
HBG1	3047	Hemoglobin, γA	0.40	6.6E − 08	0.0003	93,019
KRTAP 10-12	386,685	Keratin associated protein 10–12	0.65	1.7E − 05	0.0146	49,880
NPPA	4878	Natriuretic peptide A	0.64	4.0E − 05	0.0254	17,657
BPIFB2	80,341	BPI fold containing family B, member 2	0.60	2.6E − 05	0.0196	14,002
TUBB2A	7280	Tubulin, β2A class IIa	0.58	2.7E − 06	0.0055	8610
S100P	6286	S100 Ca²⁺ binding protein P	0.43	6.6E − 08	0.0003	5677
G3BP1	10,146	GTPase activating protein (SH3 domain) binding protein 1	0.66	2.9E − 05	0.0207	4888
NCR3	259,197	Natural cytotoxicity triggering receptor 3	0.58	9.8E − 05	0.0375	1941
SIGLEC14	100,049,587	Sialic acid Ig-like lectin 14	0.05	< E − 09	0.0000	1625
LAIR2	3904	Leukocyte-associated immunoglobulin-like receptor 2	0.62	7.1E − 05	0.0312	510
IGF2	3481	Insulin-like growth factor 2	0.57	7.4E − 05	0.0314	378
LOC 102467076	102,467,076	Uncharacterized LOC102467076	0.49	6.6E − 08	0.0004	347
RNF182	221,687	Ring finger protein 182	0.40	1.3E − 07	0.0000	140
C17orf97	400,566	Ligand of arginyltransferase 1 (LIAT1)	0.26	< E − 09	0.0000	121
C8orf17	100,507,249	Chromosome 8 open reading frame 17	0.40	1.6E − 05	0.0148	91
TEKT2	27,285	Tektin 2 (testicular)	0.59	5.3E − 05	0.0284	66
KCNJ18	100,134,444	Potassium inwardly rectifying channel subfamily J, member 18	0.65	3.6E − 05	0.0237	61
MDGA1	266,727	MAM domain containing glycosylphosphatidylinositol anchor 1	0.47	2.3E − 07	0.0007	54

Representative list of genes up-expressed (< 0.66-fold) in priests comparing to the controls. The described data is in descending ordered of the average raw signals (> 50) in the priests’ group microarray data. C17orf97 has been validated by quantitative real-time PCR (Fig. 1)

ISSN: 1479-7364