Fig. 3
From: Evaluating somatic tumor mutation detection without matched normal samples
Recall and precision of tumor-only and matched tumor-normal mutation detection. Recall and precision of methods compared to MuTect in TGS (a) and WES (b). Distributions are represented with box plots, and individual data points are plotted as asterisks. Fraction of COSMIC mutations detected by c matched tumor-normal and tumor-only methods within 182 TGS samples (left) and all TGS samples using tumor-only methods (right). d 250 WES samples. Shading indicates the number of times the mutation was observed in the COSMIC v61 database. e TGS alternate allele fraction and accuracy of KRAS G12/G13/Q61 mutations initially discovered by capillary sequencing. Not shown are the seven mutations detected in the TGS but not capillary sequencing