Table 2 Genotype frequencies and odds ratio of SNPs associated with lymphedema patients and infected controls
Gene (dbSNP rs#) | Functional category of SNP | Genotypes | Cases (%) | Controls (%) | P value | ORc (95% CI) | |
|---|---|---|---|---|---|---|---|
PATT a | Adjustedb | ||||||
CEACAM-1 (rs8110904) | Missense | AA | 26 (9) | 57 (9) | 0.024 | 0.370 | (A) 1.2 (0.99–1.49) |
AG | 182 (67) | 385 (59) | |||||
GG | 65 (24) | 213 (32) | |||||
CEACAM-1 (rs8111171) | Missense | GG | 61 (22) | 205 (31) | 0.026 | 0.370 | (T) 1.3 (1.03–1.56) |
GT | 145 (52) | 311 (46) | |||||
TT | 73 (26) | 157 (23) | |||||
FLT-4/VEGFR-3 (rs75614493) | Missense | CC | 282 (99) | 658 (96) | 0.034 | 0.232 | (C) 3.4 (1.02–11.29) |
CT | 3 (1) | 24 (4) | |||||
TT | 0 (0) | 0 (0) | |||||
MMP-2 (rs1030868) | Intron | AA | 69 (24) | 113 (17) | 0.0094 | 0.232 | (A) 1.3 (1.07–1.58) |
AG | 134 (47) | 337 (49) | |||||
GG | 82 (29) | 232 (34) | |||||
MMP-2 (rs2241145) | Intron | CC | 86 (30) | 158 (23) | 0.0116 | 0.232 | (C) 1.3 (1.06–1.57) |
CG | 136 (48) | 334 (49) | |||||
GG | 63 (22) | 190 (28) | |||||