Single nucleotide polymorphisms in the angiogenic and lymphangiogenic pathways are associated with lymphedema caused by Wuchereria bancrofti

Table 3 SNP haplotypes in genes associated with lymphedema

Gene	dbSNPrs#	Allele	Distribution cases (%)	Distribution controls (%)	P value (1df)	Global P value^a
CEACAM-1	rs8110904	G	48.3	54.0	0.026	0.092
	rs8111171	G	48.3	54.0	0.026	0.092
	rs8110904	A	48.0	39	0.046	0.092
	rs8111171	T	48.0	39	0.046	0.092
VEGFR-3	rs75614493	T	0.5	1.8	0.023	0.080
VEGFR-3	rs3587489	T	0.5	1.8	0.023	0.080
MMP-2	rs2241145	T	33.1	28.3	0.046	0.030
	rs1030868	A
	rs11643630	C
	rs1992116	G

Italic text indicates a significant association
^aCalculated by an omnibus statistic with 200,000 simulations in FamHap version 19

ISSN: 1479-7364