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Table 1 Clinical and biochemical characteristics in the normotensive controls and HTN patient subgroups according to the antihypertensive therapy

From: The peptidylglycine-α-amidating monooxygenase (PAM) gene rs13175330 A>G polymorphism is associated with hypertension in a Korean population

 

Normotensive controls (n = 1610)

HTN group (n = 543)

Total (n = 543)

HTN w/o therapy (n = 377)

HTN w/ therapy (n = 166)

Age (years)

48.0

± 0.27

54.4

± 0.50***

53.0

± 0.61***

57.7

± 0.83***

Weight (kg)

63.0

± 0.25

68.1

± 0.51***

68.9

± 0.64***

66.3

± 0.81***

BMI (kg/m2)

23.7

± 0.07

25.4

± 0.14***

25.4

± 0.17***

25.2

± 0.22***

Waist (cm)

83.5

± 0.19

87.9

± 0.37***

87.9

± 0.46***

88.0

± 0.63***

Waist hip ratio

0.88

± 0.00

0.90

± 0.00***

0.90

± 0.00***

0.91

± 0.00***

Systolic BP (mmHg)

116.4

± 0.29

138.5

±0.66***

145.2

± 0.62***

123.2

± 0.79***

Diastolic BP (mmHg)

72.7

± 0.22

87.4

± 0.46***

91.8

± 0.42***

77.4

± 0.66***

Triglyceride (mg/dL)a

119.6

± 1.84

148.6

± 3.76***

151.2

± 4.79***

142.8

± 5.72***

Total-cholesterol (mg/dL)a

198.1

± 0.90

198.3

± 1.54

200.2

± 1.87

193.9

± 2.68

HDL-cholesterol (mg/dL)a

53.9

± 0.34

50.4

± 0.55***

50.3

± 0.65***

50.5

± 1.03**

LDL-cholesterol (mg/dL)a

121.1

± 0.82

119.1

± 1.42

120.7

± 1.77

115.4

± 2.31

Glucose (mg/dL)a

95.6

± 0.51

103.9

± 1.11***

103.9

± 1.40***

103.9

± 1.73***

Insulin (μIU/dL)a

9.09

± 0.12

9.84

± 0.25*

10.1

± 0.33*

9.73

± 0.35*

HOMA-IRa

2.15

± 0.03

2.55

± 0.09***

2.65

± 0.12***

2.44

± 0.09***

LDL particle size (nm)a

23.9

± 0.03

24.0

± 0.05

23.9

± 0.06

24.0

± 0.08

Oxidized LDL (U/L)a

46.1

± 0.53

48.3

± 0.97*

50.8

± 1.15***

43.7

± 1.75

  1. Mean ± SE
  2. HTN hypertension, HTN w/o therapy HTN group treated without antihypertensive therapy, HTN w/ therapy HTN group treated with antihypertensive therapy, BMI body mass index, BP blood pressure, HDL high-density lipoprotein, LDL low-density lipoprotein, HOMA-IR homeostatic model assessment of insulin resistance
  3. * p < 0.05, ** p < 0.01, and *** p < 0.001 derived from an independent t test between the normotensive controls and each HTN subgroup
  4. aTested following logarithmic transformation