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Table 1 Clinical and biochemical characteristics in the normotensive controls and HTN patient subgroups according to the antihypertensive therapy

From: The peptidylglycine-α-amidating monooxygenase (PAM) gene rs13175330 A>G polymorphism is associated with hypertension in a Korean population

  Normotensive controls (n = 1610) HTN group (n = 543)
Total (n = 543) HTN w/o therapy (n = 377) HTN w/ therapy (n = 166)
Age (years) 48.0 ± 0.27 54.4 ± 0.50*** 53.0 ± 0.61*** 57.7 ± 0.83***
Weight (kg) 63.0 ± 0.25 68.1 ± 0.51*** 68.9 ± 0.64*** 66.3 ± 0.81***
BMI (kg/m2) 23.7 ± 0.07 25.4 ± 0.14*** 25.4 ± 0.17*** 25.2 ± 0.22***
Waist (cm) 83.5 ± 0.19 87.9 ± 0.37*** 87.9 ± 0.46*** 88.0 ± 0.63***
Waist hip ratio 0.88 ± 0.00 0.90 ± 0.00*** 0.90 ± 0.00*** 0.91 ± 0.00***
Systolic BP (mmHg) 116.4 ± 0.29 138.5 ±0.66*** 145.2 ± 0.62*** 123.2 ± 0.79***
Diastolic BP (mmHg) 72.7 ± 0.22 87.4 ± 0.46*** 91.8 ± 0.42*** 77.4 ± 0.66***
Triglyceride (mg/dL)a 119.6 ± 1.84 148.6 ± 3.76*** 151.2 ± 4.79*** 142.8 ± 5.72***
Total-cholesterol (mg/dL)a 198.1 ± 0.90 198.3 ± 1.54 200.2 ± 1.87 193.9 ± 2.68
HDL-cholesterol (mg/dL)a 53.9 ± 0.34 50.4 ± 0.55*** 50.3 ± 0.65*** 50.5 ± 1.03**
LDL-cholesterol (mg/dL)a 121.1 ± 0.82 119.1 ± 1.42 120.7 ± 1.77 115.4 ± 2.31
Glucose (mg/dL)a 95.6 ± 0.51 103.9 ± 1.11*** 103.9 ± 1.40*** 103.9 ± 1.73***
Insulin (μIU/dL)a 9.09 ± 0.12 9.84 ± 0.25* 10.1 ± 0.33* 9.73 ± 0.35*
HOMA-IRa 2.15 ± 0.03 2.55 ± 0.09*** 2.65 ± 0.12*** 2.44 ± 0.09***
LDL particle size (nm)a 23.9 ± 0.03 24.0 ± 0.05 23.9 ± 0.06 24.0 ± 0.08
Oxidized LDL (U/L)a 46.1 ± 0.53 48.3 ± 0.97* 50.8 ± 1.15*** 43.7 ± 1.75
  1. Mean ± SE
  2. HTN hypertension, HTN w/o therapy HTN group treated without antihypertensive therapy, HTN w/ therapy HTN group treated with antihypertensive therapy, BMI body mass index, BP blood pressure, HDL high-density lipoprotein, LDL low-density lipoprotein, HOMA-IR homeostatic model assessment of insulin resistance
  3. * p < 0.05, ** p < 0.01, and *** p < 0.001 derived from an independent t test between the normotensive controls and each HTN subgroup
  4. aTested following logarithmic transformation