Table 3 Gene clustering per metabolic or disease network using Ingenuity Pathway Analysis (IPA) to assist decision-making
Disease or metabolic network | Genes | p value |
|---|---|---|
Neural cell proliferation | ISL1, FTO, ADCYAP1, ΟΤΡ, SPP1 | 6.02 × 10–5 |
Motor neuron proliferation | ISL1, FTO | 9.53 × 10–5 |
Motor neuron dysfunction | ISL1, WNT4 | 1.28 × 10–3 |
Development of neuromuscular junction | PDZRN3 | 1.65 × 10–3 |
Branching of sensory neurons | PRKG1 | 1.65 × 10–3 |
ALS | FUS | 1.65 × 10–3 |
Development of P and M cells of visual nervous system | ΟΤΡ | 1.65 × 10–3 |
Growth of cerebellar cortex, regulation of upper cervical ganglia | ADCYAP1 | 1.65 × 10–3 |
Cranial nerve development | ISL1, ERBB4 | 1.9 × 10–3 |
Brain development | ADCYAP1, ERBB4, FTO, ΟΤΡ, PRKG1 | 2.56 × 10–3 |
Development of specific nerves of the hand, area of dendritic trees | ISL1 | 3.3 × 10–3 |
Movement of the cranial neural crest, participation in the formation of the central nervous system, astrocyte attachment | ERBB4 | 3.3 × 10–3 |
Neural cell number | ADCYAP1, ERBB4, WNT4, SPP1 | 3.75 × 10–3 |
Nervous system morphology | ERBB4, FTO, WNT4, SPP1, YES1, ISL1 | 6.33 × 10–3 |
Oligodendrocyte development, excitatory synapse formation | ERBB4 | 6.6 × 10–3 |
Central nervous system development, dendritic cell development | ERBB4, ADCYAP1 | 7.4 × 10–3 |
Motor neuron sprouting | FTO | 9.88 × 10–3 |
v3 spinal cord motor neuron sprouting | FTO | 9.88 × 10–3 |
Midbrain size | FTO | 9.88 × 10–3 |
Neuronal withdrawal | WNT4 | 1.32 × 10–2 |
Brain morphology | ERBB4, FTO, SPP1, YES1 | 1.35 × 10–2 |
Neuronal branching | ERBB4, ADCYAP1, PRKG1 | 1.58 × 10–2 |
DNA repair | APTX, FTO, FUS | 1.65 × 10–2 |