Skip to main content

Table 3 Gene clustering per metabolic or disease network using Ingenuity Pathway Analysis (IPA) to assist decision-making

From: Genomic variants in the FTO gene are associated with sporadic amyotrophic lateral sclerosis in Greek patients

Disease or metabolic network Genes p value
Neural cell proliferation ISL1, FTO, ADCYAP1, ΟΤΡ, SPP1 6.02 × 10–5
Motor neuron proliferation ISL1, FTO 9.53 × 10–5
Motor neuron dysfunction ISL1, WNT4 1.28 × 10–3
Development of neuromuscular junction PDZRN3 1.65 × 10–3
Branching of sensory neurons PRKG1 1.65 × 10–3
ALS FUS 1.65 × 10–3
Development of P and M cells of visual nervous system ΟΤΡ 1.65 × 10–3
Growth of cerebellar cortex, regulation of upper cervical ganglia ADCYAP1 1.65 × 10–3
Cranial nerve development ISL1, ERBB4 1.9 × 10–3
Brain development ADCYAP1, ERBB4, FTO, ΟΤΡ, PRKG1 2.56 × 10–3
Development of specific nerves of the hand, area of dendritic trees ISL1 3.3 × 10–3
Movement of the cranial neural crest, participation in the formation of the central nervous system, astrocyte attachment ERBB4 3.3 × 10–3
Neural cell number ADCYAP1, ERBB4, WNT4, SPP1 3.75 × 10–3
Nervous system morphology ERBB4, FTO, WNT4, SPP1, YES1, ISL1 6.33 × 10–3
Oligodendrocyte development, excitatory synapse formation ERBB4 6.6 × 10–3
Central nervous system development, dendritic cell development ERBB4, ADCYAP1 7.4 × 10–3
Motor neuron sprouting FTO 9.88 × 10–3
v3 spinal cord motor neuron sprouting FTO 9.88 × 10–3
Midbrain size FTO 9.88 × 10–3
Neuronal withdrawal WNT4 1.32 × 10–2
Brain morphology ERBB4, FTO, SPP1, YES1 1.35 × 10–2
Neuronal branching ERBB4, ADCYAP1, PRKG1 1.58 × 10–2
DNA repair APTX, FTO, FUS 1.65 × 10–2