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Table 2 Significant correlations among candidate gene expression levels

From: Correlation of gene expression and associated mutation profiles of APOBEC3A, APOBEC3B, REV1, UNG, and FHIT with chemosensitivity of cancer cell lines to drug treatment

Gene 1

Gene 2

n

ρ

p

p adj

Cancer category

Within individual cancer categories

APOBEC3B

APOBEC3A

186

0.741

1.15 × 10−33

2.64 × 10−31

NSCLC

APOBEC3B

APOBEC3A

5

1.000

1.40 × 10−24

1.61 × 10−22

LAML

APOBEC3B

APOBEC3A

62

0.759

8.88 × 10−13

6.81 × 10−11

COAD/READ

APOBEC3B

APOBEC3A

78

0.690

2.83 × 10−12

1.44 × 10−10

CLLE

APOBEC3B

APOBEC3A

79

0.686

3.12 × 10−12

1.44 × 10−10

GLIOMA

APOBEC3B

APOBEC3A

38

0.811

6.60 × 10−10

2.53 × 10−8

STAD

APOBEC3B

APOBEC3A

51

0.712

4.82 × 10−9

1.58 × 10−7

OVARIAN

APOBEC3B

APOBEC3A

44

0.746

6.12 × 10−9

1.76 × 10−7

PAAD

APOBEC3B

APOBEC3A

60

0.651

1.73 × 10−8

4.43 × 10−7

MATBCL

APOBEC3B

APOBEC3A

59

0.612

2.65 × 10−7

6.09 × 10−6

BREAST

APOBEC3B

APOBEC3A

26

0.805

7.04 × 10−7

1.47 × 10−5

EC

UNG

REV1

186

0.344

1.56 × 10−6

2.98 × 10−5

NSCLC

APOBEC3B

APOBEC3A

59

0.576

1.81 × 10−6

3.20 × 10−5

MEL

APOBEC3B

APOBEC3A

27

0.773

2.30 × 10−6

3.78 × 10−5

BLADDER

APOBEC3B

APOBEC3A

43

0.639

3.95 × 10−6

6.06 × 10−5

SAR

APOBEC3B

APOBEC3A

36

0.637

3.00 × 10−5

0.0004

RCC

APOBEC3B

APOBEC3A

34

0.645

3.83 × 10−5

0.0005

LIHC

APOBEC3B

APOBEC3A

22

0.747

6.48 × 10−5

0.0008

CESC

APOBEC3B

APOBEC3A

33

0.636

6.87 × 10−5

0.0008

HNSC

APOBEC3B

FHIT

79

− 0.407

0.0002

0.0022

GLIOMA

APOBEC3B

APOBEC3A

28

0.632

0.0003

0.0034

MM

APOBEC3B

APOBEC3A

13

0.769

0.0021

0.0221

THCA

APOBEC3B

UNG

60

− 0.372

0.0034

0.0342

MATBCL

APOBEC3A

UNG

78

− 0.324

0.0039

0.0369

CLLE

APOBEC3B

APOBEC3A

6

0.943

0.0048

0.0442

UCEC

Across all cancer categories

APOBEC3B

APOBEC3A

1036

0.714

1.91 × 10−162

1.91 × 10−161

Pan-cancer

UNG

REV1

1036

0.189

8.04 × 10−10

4.02 × 10−9

Pan-cancer

APOBEC3B

REV1

1036

− 0.118

0.0001

0.0005

Pan-cancer

APOBEC3B

FHIT

1036

− 0.088

0.0046

0.0115

Pan-cancer

APOBEC3B

UNG

1036

− 0.070

0.0251

0.0426

Pan-cancer

APOBEC3A

UNG

1036

− 0.068

0.0291

0.0426

Pan-cancer

UNG

FHIT

1036

0.068

0.0298

0.0426

Pan-cancer

  1. Listed are significant correlations with padj < 0.05. The p values were adjusted for false discovery rate accounting for five genes (Ntests = 10). Among individual cancer categories, FDR adjustment also accounted for 23 cancer categories with ≥ 5 cell lines with available expression data in both genes (Ntests = 230). Abbreviations of cancer categories are provided in the legend of Table 1
  2. n sample size for correlation analysis, ρ Spearman correlation coefficient, p p value prior to FDR adjustment, p adj FDR-adjusted p value