Correlation of gene expression and associated mutation profiles of APOBEC3A, APOBEC3B, REV1, UNG, and FHIT with chemosensitivity of cancer cell lines to drug treatment

Table 4 Prevalence of APOBEC mutation motifs and kataegis clusters in a combined analysis of all cancer categories

Measure	T(C>K)W		T(C>D)R		T(C>D)D
Measure	Range	Mean ± SD	Range	Mean ± SD	Range	Mean ± SD
Total motif count	381–1369	603.58 ± 121.17	465–4633	743.51 ± 317.68	715–13,461	1184.94 ± 887.46
Predicted non-overlapping kataegis clusters, 5/1000
Number of motifs in distinct clusters	0–16	0.6 ± 1.87	0–21	2.9 ± 3.99	0–69	10.71 ± 6.8
Number of distinct clusters	0–3	0.12 ± 0.36	0–4	0.56 ± 0.77	0–11	2 ± 1.2
Combined length (bp) of distinct clusters	0–1994	76.95 ± 238.6	0–3148	418.47 ± 615.59	0–7484	1327.31 ± 894.04
Predicted non-overlapping kataegis clusters, 6/10000
Number of motifs in distinct non-overlapping clusters	0–95	0.87 ± 6.08	0–93	3.93 ± 8.34	0–221	10.26 ± 16.69
Number of distinct non-overlapping clusters	0–10	0.11 ± 0.67	0–8	0.53 ± 0.86	0–18	1.45 ± 1.65
Combined length (bp) of distinct clusters	0–89,163	750.11 ± 5802.03	0–78,974	2997.94 ± 7701	0–147,285	5323.27 ± 12,925.39

Shown are values per cell line, computed using whole-exome sequence data of each cell line
SD standard deviation, 5/1000 a kataegis cluster with ≥ 5 motifs on the same genome strand per 1000 bp, 6/10000 a kataegis cluster with ≥ 6 motifs on the same genome strand per 10,000 bp

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