Correlation of gene expression and associated mutation profiles of APOBEC3A, APOBEC3B, REV1, UNG, and FHIT with chemosensitivity of cancer cell lines to drug treatment

Table 5 Statistically significant correlations of gene expression levels with mutation counts

Gene	Mutation count	n	ρ	p	p _adj	Cancer type
REV1	C>K^b	12	− 0.902	6.00 × 10⁻⁵	0.0114	Sarcoma
REV1	C>K^a	12	− 0.895	8.37 × 10⁻⁵	0.0114	Sarcoma
REV1	C>T^b	12	− 0.895	8.37 × 10⁻⁵	0.0114	Sarcoma
REV1	Any	12	− 0.881	0.0002	0.0114	Sarcoma
REV1	C>T^a	12	− 0.881	0.0002	0.0114	Sarcoma
REV1	C>G^a	12	− 0.867	0.0003	0.0119	Sarcoma
REV1	C>G^b	12	− 0.867	0.0003	0.0119	Sarcoma
UNG	C>K^a	17	− 0.816	6.45 × 10⁻⁵	0.0114	Melanoma
UNG	Any	17	− 0.799	0.0001	0.0114	Melanoma
UNG	C>K^b	17	− 0.797	0.0001	0.0114	Melanoma
UNG	C>G^a	17	− 0.787	0.0002	0.0118	Melanoma
UNG	C>T^a	17	− 0.779	0.0002	0.0119	Melanoma
UNG	C>T^b	17	− 0.777	0.0002	0.0119	Melanoma
UNG	C>G^b	17	− 0.738	0.0007	0.0308	Melanoma

Shown are correlations of gene expression levels with overall mutation counts in the WES data with p_adj < 0.05. These p values were FDR adjusted for multiple comparisons that included 5 candidate genes, 17 cancer categories with ≥ 5 cell lines in each category having both WES and expression data, and 7 categories of mutation counts including C>T, C>G, and C>K on one or both genome strands, as well as overall single nucleotide variant counts (N_tests = 595). “>” indicates the direction of substitution change
Any all types of nucleotide substitutions, K G or T, n sample size for correlation analysis, ρ Spearman correlation coefficient, p p value prior to FDR adjustment, p_adj FDR-adjusted p value
^aMutation counts on the reference genome strand only
^bMutation counts on both genome strands

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