| Data type and sensitivity | Data available from | Governance | Data distribution |
---|---|---|---|---|
Class 1 | Low risk survey/phenotype-only data, e.g. social, economic, psychological and health data. | UK Data Archive | Requires registered access—online (clickable) end-user licences. | Data is distributed by the UK Data Archive. |
Class 2 | Low sensitivity genetic-only data, e.g. genome-wide single nucleotide polymorphism [SNP] data generated from a standard chip with no phenotype information except gender and a coarse measure of area of residence. | European Genome-phenome Archive (EGA) | Requires application to the Sanger DAC, administrative decision based on algorithm of criteria for access. | Data are distributed by the EGA. |
Class 3 | Potentially disclosive survey/phenotype-only data, e.g. small geographic area. Requires application to a study-based Data Access Committee made up of study investigators and study technical staff. | Study DAC | Data may be issued on special licence or may be accessible only in on or off-site data safe havens. | Data is distributed, or the data safe haven hosted, by the study. |
Class 4 | New forms of genetic-only data, e.g. exome sequence and epigenetic data, are reviewed by METADAC until their ethical implication/sensitivity is established. | METADAC | Application requires review and approval from the METADAC Access Committee. Application includes signed agreement to conditions of use. Data use is monitored annually. | Data are distributed by the EGA. |
Class 5 | Genetic-only data with known ethical issues, e.g. incidental findings risk in exome data. | METADAC | Application requires review and approval from the METADAC Access Committee. Application includes signed agreement to conditions of use. Data use is monitored annually. | Data are distributed by the EGA. |
Class 6 | Biological samples. Use of biological samples will always require additional oversight for ethical and scientific reasons. | METADAC | Application requires independent scientific review and approval from the METADAC Access Committee. | Samples are issued by the relevant study under Material Transfer Agreements. |
Class 7 | Any combination of Classes 1 to 6, e.g. individual-level phenotype data linked to genotype data or samples, is potentially more disclosive than any one class of data alone. | METADAC | Application requires review and approval from the METADAC Access Committee. Application includes signed agreement to conditions of use. Data use is monitored annually. | Combined datasets are issued on unique IDs and distributed by the study and EGA. |
Class 8 | Non-research data. High risk when multiple variables are combined. | Various | Certain administrative datasets, e.g. education and criminal records, are available for research via the Administrative Data Research Network. Individual-level health data is available for research via NHS Digital). | Various |