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Table 4 Comparison of publicly available mutated keratin 16 and keratin 17 sequence data of various skin disease patients with mutated sequence obtained in our study (psoriasis) from Clinvar NCBI database

From: Mutational analysis of epidermal and hyperproliferative type I keratins in mild and moderate psoriasis vulgaris patients: a possible role in the pathogenesis of psoriasis along with disease severity

S. no. Name Gene(s) Condition(s) Clinical significance (last reviewed) GRCh37 GRCh38 Variation ID Allele ID(s)
Chromosome Location Chromosome Location
1 NM_005557.3(KRT16):c.395T > C (p.Leu132Pro) KRT16 PC 1 Pathogenic (Jan 29, 2016) 17 39768546 17 41612294 14600 29639
2 NM_005557.3(KRT16):c.379C > G (p.Arg127Gly) KRT16 Not provided Pathogenic (May 11, 2015) 17 39768562 17 41612310 265217 260165
3 NM_000422.2(KRT17):c.1163T > C (p.Leu388Pro) KRT17 Not provided Not provided 17 39776929 17 41620677 66181 77078
4 NM_000422.2(KRT17):c.1112T > C (p.Leu371Pro) KRT17 Not provided Not provided 17 39776980 17 41620728 66180 77077
5 NM_000422.2(KRT17):c.325A > G (p.Asn109Asp) KRT17 Not provided Not provided 17 39780437 17 41624185 66188 77085
6 NM_000422.2(KRT17):c.309T > C (p.Arg103=) KRT17 Not provided Not provided 17 39780453 17 41624201 66187 77084
7 NM_000422.2(KRT17):c.304G > A (p.Val102Met) KRT17 PC 2 Pathogenic (Mar 1, 2002) 17 39780458 17 41624206 14599 29638
8 NM_000422.2(KRT17):c.296T > C (p.Leu99Pro) KRT17 PC 2 Pathogenic (Jun 9, 2015) 17 39780466 17 41624214 14598 29637
9 NM_000422.2(KRT17):c.292T > G (p.Tyr98Asp) KRT17 PC 2 Pathogenic (Feb 1, 1997) 17 39780470 17 41624218 14588 29627
10 NM_000422.2(KRT17):c.284T > C (p.Leu95Pro) KRT17 PC 2 Pathogenic (May 14, 2015) 17 39780478 17 41624226 14596 29635
11 NM_000422.2(KRT17):c.284T > A (p.Leu95Gln) KRT17 PC 2 Pathogenic (May 1, 2001) 17 39780478 17 41624226 14595 29634
12 NM_000422.2(KRT17):c.281G > C (p.Arg94Pro) KRT17 PC 2 Pathogenic (May 1, 2001) 17 39780481 17 41624229 14594 29633
13 NM_000422.2(KRT17):c.281G > A (p.Arg94His) KRT17 PC 2| SM Pathogenic (Dec 1, 2001) 17 39780481 17 41624229 14590 29629
14 NM_000422.2(KRT17):c.280C > T (p.Arg94Cys) KRT17 PC 2| Pathogenic(Aug 15, 2016) 17 39780482 17 41624230 14591 29630
15 NM_000422.2(KRT17):c.275A > G (p.Asn92Ser) KRT17 PC 2 Pathogenic (Jul 26, 2016) 17 39780487 17 41624235 14587 29626
16 NM_000422.2(KRT17):c.274A > C (p.Asn92His) KRT17 SM Pathogenic (Feb 1, 1997) 17 39780488 17 41624236 14589 29628
17 NM_000422.2(KRT17):c.274A > G (p.Asn92Asp) KRT17 PC 2 Pathogenic (Nov 3, 2016) 17 39780488 17 41624236 14586 29625
18 NM_000422.2(KRT17):c.263T > A (p.Met88Lys) KRT17 Not provided Not provided 17 39780499 17 41624247 66182 77079
19 NM_000422.2(KRT17):c.263T > C (p.Met88Thr) KRT17 PC 2 Pathogenic (Nov 1, 1999) 17 39780499 17 41624247 14592 29631
20 NM_000422.2(KRT17):c.-6G > C KRT17 Not specified Benign (Apr 28, 2016) 17 39780767 17 41624515 380281 375886
  1. PC pachyonychia congenita, SM steatocystoma multiplex