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Fig. 8 | Human Genomics

Fig. 8

From: Oxidative stress-induced chromosome breaks within the ABL gene: a model for chromosome rearrangement in nasopharyngeal carcinoma

Fig. 8

A map representing the positions of H2O2-induced chromosome breaks within the ABL gene. a The ABL genomic map from nucleotide positions 601-174330 is illustrated above [Ensembl:ENSG00000097007]. The locations of exons 1–11 are shown. The green boxes indicate the three previously identified patient breakpoints cluster regions which are designated as BCRA, BCRB and BCRC. The yellow box shows the previously biochemically extracted MAR/SAR which is indicated as SAR1 [77]. The yellow arrows represent the potential MAR/SARs predicted by MRS in this study. b The region of study (3.7 kb). Xba I (X), BsaA I (B), Age I (A) and EcoR I (E) restriction sites are shown. The green and blue arrows represent the primers used in the first and second rounds of nested IPCR, respectively. The breakpoints identified in H2O2-treated HK1 and NP69 cells are indicated by the green and red vertical lines, respectively. All chromosome breaks were mapped within SAR1

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