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Table 1 Enzymatic mechanisms used for histone acetylation

From: The tale of histone modifications and its role in multiple sclerosis

Canonical members of KAT

Former name in human

Histone protein acetylated

Mechanism of catalysis

P300/CBP family

KAT3

  

Hit-and-run

 KAT3A

CBP

H2A, H2B

 KAT3B

P300

H2A, H2B

GCN5 family

KAT2

  

KAT/Ac-CoA/substrate ternary complex

 KAT2A

GCN5

H3, H4,H2B

 KAT2B

PCAF

H3

MYST family

KAT5

Tip60

H4, H2AZ, H2AX

Ping-pong mechanism or ternary mechanism

KAT6

 KAT6A

MOZ/MYST3

H3

 KAT6B

MORF/MYST4

 

 KAT7

HBO1/MYST2

H4

 KAT8

MOF/MYST1

H4