Fig. 1
From: Abundance of clinical variants in exons included in multiple transcripts
Relationship between the exon inclusion measures and the ratio of nonsynonymous-to-synonymous divergences (dN/dS). a Exon inclusion level. b Exon inclusion ratio. Synonymous and nonsynonymous divergences were estimated using the Kimura two parameter model [11]. Error bars show the standard error of the mean, which were calculated using the analytical variance of the Kimura two parameter method [11]. The relationships were highly significant (ρ = − 0.98 and ρ = − 0.95 respectively; P < 0.001) using the Spearman’s rank correlation. Note that in a, the last value (> 10 exons) on the X-axis was taken as 11 exons to calculate the correlation coefficient and significance