Fig. 3
From: A new bioinformatics tool to help assess the significance of BRCA1 variants
Position of the variants with defects in ubiquitin transferase activity, BARD1 binding, and UBE2D1 binding for the first 300 BRCA1 residues. Positions where variations have no or mild impact are shown in green, those with moderate effects in yellow, and those with severe defects in red. The positions with no data are in white. The RING domain is indicated (positions 24 to 65)