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Fig. 4 | Human Genomics

Fig. 4

From: A new bioinformatics tool to help assess the significance of BRCA1 variants

Fig. 4

Screenshot of the neXtProt Cancer variant portal. Evidence for the triplet “Ser1715Asn decreases transcription, DNA-templated”. There are three evidences supporting this statement based on two papers, annotated as “Severe” because of the amplitude of the activity reduction in each study. One of the evidences is tagged as “Silver” because the human BRCA1 variant was analyzed in a yeast system, which the curator judged less reliable since yeast does not have a BRCA1 ortholog

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