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Fig. 3 | Human Genomics

Fig. 3

From: Forward and reverse mutations in stages of cancer development

Fig. 3

SNV mutations in B-N-T trio samples. a Genotypic changes in N- or T-stage of the samples. The numbers of genotypic changes in N- or T-stage sequences relative to B-stage sequences are represented by ΔNB and ΔTB, respectively. The 17 B-N-T trio samples consisted of 1 BRCA, 2 LIHC, and 14 non-small cell lung cancer (NSCLC) cases. b Patch diagrams tracing SNVs between the B-, N-, and T-samples. c Mutational profiles for the ∆NB and ∆TN SNV changes as numerically indicated in the patch diagrams in part b. In each vertical bar in the ∆NB tier, the solid segment represents the SNVs that were reversed in the ∆TN tier, whereas the open segment indicates the unreversed SNVs (see Additional files 7 and 8: Tables S6 and S7 for details of SNVs, and Fig. 1 for abbreviations)

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