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Table 4 Validation analysis of five genes using five GEO datasets

From: Bayesian variable selection for parametric survival model with applications to cancer omics data

Gene symbol

GSE14210 (N = 119)

GSE15459 (N = 197)

GSE29272 (N = 126)

GSE51105 (N = 93)

GSE62254 (N = 283)

Heterogeneity-P (I2)

Combined (random)

CTLA4 (2q33.2)

–a

0.77 (0.52~1.12)

1.7E−01

–

0.45 (0.25~0.82)

7.6E−03

0.59 (0.41~0.85)

4.1E−03

3.0E−01

16.9%

0.62 (0.48~0.82)

5.6E−04

PLCXD3 (5p13.1)

–

0.77 (0.51~1.15)

2.0E−01

–

1.60 (0.98~2.6)

5.8E−02

1.92 (1.32~2.79)

5.0E−04

4.0E−03

82.1%

1.33 (0.75~2.36)

3.3E−01

NACAD (7p13)

1.47 (0.97~2.24)

7.1E−02

1.47 (0.93~2.34)

9.8E−02

1.61 (1.04~ 2.49)

3.0E−02

1.76 (1.06~2.92)

2.7E−02

2.03 (1.41~2.92)

9.3E−05

7.7E−01

0.0%

1.68 (1.39~2.04)

1.2E−07

SERPINE1 (7q22.1)

1.46 (0.99~2.16)

5.6E−02

0.83 (0.56~1.24)

3.7E−01

0.73 (0.48~ 1.10)

1.3E−01

1.27 (0.76~2.12)

3.7E−01

1.57 (1.08~2.28)

1.6E−02

2.2E−02

65.0%

1.12 (0.82~1.53)

4.7E−01

GAMT (19p13.3)

1.17 (0.81~1.70)

4.0E−01

0.69 (0.46~1.03)

6.6E−02

1.81 (1.07~ 3.06)

2.6E−02

0.54 (0.32~0.92)

2.2E−02

1.75 (1.22~2.51)

2.2E−03

< 1.0E−03

81.8%

1.08 (0.69~1.68)

7.5E−01

  1. The contents of each cell represent estimated hazard ratio (HR), 95%CI of HR, and hypothesis testing P value of HR, and in each dataset, the samples are categorized into two groups using a best cutoff of expression level. Combined results are derived by meta-analysis with random effect model
  2. aExpression data of the gene is not available in the corresponding GEO database