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Table 1 Twenty-four SNP pairs that were significant in both single- and multi-SNP–multi-trait analyses

From: Multiple genotype–phenotype association study reveals intronic variant pair on SIDT2 associated with metabolic syndrome in a Korean population

SNP pair

Gene

Publication of mapped gene in GWAS catalog

P value from a single SNP-multi trait analysis

P value from multi SNP-multi trait analysis

(A Bonferroni-adjusted P value = 1.45 × 10−7)

Discovery

Replication

Meta P value

Discovery

Replication

Meta P value

rs2293571, rs780094

GCKR

[6, 19, 20, 36]

2.39E-03, 2.55E-12

9.46E-02, 1.85E-06

2.12E-03, 1.93E-16

4.98E-14

6.21E-05

1.28E-16

rs780094, rs780092

GCKR

[6, 19, 20, 36]

2.55E-12, 2.08E-11

1.85E-06, 1.36E-02

1.93E-16, 8.46E-12

2.02E-14

5.62E-05

4.80E-17

rs780092, rs8179252

GCKR

[6, 19, 20, 36]

2.08E-11, 1.93E-03

1.36E-02, 1.26E-02

8.46E-12, 2.83E-04

1.02E-13

4.17E-05

1.74E-16

rs263, rs271

LPL

[6, 19, 37]

2.09E-10, 6.96E-11

1.40E-05, 1.57E-05

1.01E-13, 3.87E-14

2.30E-09

2.43E-05

1.76E-12

rs12545984, rs10503669

LPL-SLC18A1

[6, 19, 37]

2.43E-01, 1.74E-15

2.24E-01, 9.06E-11

2.13E-01,9.16E-24

1.81E-14

9.20E-10

8.90E-22

rs10503669, rs17410962

LPL-SLC18A1

[6, 19, 37]

1.74E-15, 1.85E-16

9.06E-11, 4.76E-11

9.16E-24, 5.37E-25

3.35E-14

5.28E-09

9.04E-21

rs17489282, rs4922117

LPL-SLC18A1

[6, 19, 37]

4.80E-12, 1.09E-12

2.82E-07, 1.82E-07

5.70E-17, 8.74E-18

3.35E-11

6.59E-06

8.18E-15

rs765547, rs11986942

LPL-SLC18A1

[6, 19, 37]

7.30E-13, 1.54E-12

3.55E-07, 1.46E-07

1.13E-17, 9.88E-18

1.79E-11

2.43E-07

1.78E-16

rs11986942, rs1837842

LPL-SLC18A1

[6, 19, 37]

1.54E-12, 2.16E-12

1.46E-07, 3.57E-07

9.88E-18, 3.29E-17

1.21E-10

1.24E-06

5.62E-15

rs1837842, rs1919484

LPL-SLC18A1

[6, 19, 37]

2.16E-12, 1.57E-12

3.57E-07, 4.14E-07

3.29E-17, 2.79E-17

4.43E-10

3.19E-05

4.65E-13

rs1919484, rs7461115

LPL-SLC18A1

[6, 19, 37]

1.57E-12, 1.77E-12

4.14E-07, 2.61E-07

2.79E-17, 2.00E-17

8.62E-11

1.68E-05

5.09E-14

rs7013777, rs4442164

LPL-SLC18A1

[6, 19, 37]

7.61E-13, 1.08E-01

2.12E-07, 3.63E-01

7.14E-18, 1.66E-01

1.40E-16

1.09E-07

8.17E-22

rs4442164, rs4244457

LPL-SLC18A1

[6, 19, 37]

1.08E-01, 3.42E-14

3.63E-01, 4.04E-06

1.66E-01, 6.14E-18

1.39E-15

1.50E-05

9.66E-19

rs4244457, rs4449813

LPL-SLC18A1

[6, 19, 37]

3.42E-14, 3.20E-01

4.04E-06, 2.28E-01

6.14E-18, 2.64E-01

3.54E-14

1.69E-05

2.57E-17

rs12686004, rs3905000

ABCA1

[6]

1.25E-09, 6.74E-02

1.13E-02, 7.66E-01

3.67E-10, 2.05E-01

3.08E-10

4.22E-02

3.39E-10

rs481843, rs486394

LOC101929011

[38]

2.40E-06, 4.03E-08

6.85E-03, 1.79E-03

3.11E-07, 1.76E-09

3.33E-08

1.85E-02

1.37E-08

rs180344, rs11216126

LOC101929011-BUD13

[19, 38]

9.22E-02, 3.70E-20

9.04E-01, 3.25E-08

2.90E-01, 7.57E-26

5.54E-20

5.66E-07

1.87E-24

rs6589566, rs603446

ZPR1

[6]

8.27E-26, 9.02E-14

2.69E-12, 1.15E-05

1.90E-35, 4.40E-17

1.03E-28

3.51E-12

3.32E-38

rs11600380, rs6589567

APOA5-APOA4

[38]

8.27E-06, 1.14E-06

2.95E-02, 1.82E-05

3.96E-06, 5.31E-10

6.60E-09

2.32E-05

4.67E-12

rs12279433, rs11827828

SIK3

–

2.29E-07, 3.35E-05

2.85E-05, 6.27E-01

1.75E-10, 2.47E-04

1.35E-09

6.84E-04

2.65E-11

rs11827828, rs2044426

SIK3

–

3.35E-05, 2.23E-07

6.27E-01, 9.96E-06

2.47E-04, 6.18E-11

1.30E-09

2.84E-04

1.09E-11

rs10892044, rs11216186

SIK3

–

7.85E-05, 1.14E-06

6.58E-01, 5.91E-05

5.62E-04, 1.65E-09

1.64E-08

1.40E-03

5.85E-10

rs2074356, rs11066194

HECTD4

[21]

8.85E-24, 4.83E-02

9.27E-07, 4.76E-01

5.58E-28, 1.10E-01

1.19E-20

2.49E-05

1.70E-23

rs11631342, rs6494005

LIPC

[6, 19]

6.22E-08, 1.41E-10

3.16E-01, 1.51E-02

3.68E-07, 5.93E-11

1.63E-14

1.24E-02

7.51E-15

  1. SNPs that are listed in GWAS catalog are shown in boldface
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Human Genomics

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