Table 2 Three SNP pairs that were significant only in the multi-SNP–multi-trait analysis
SNP pair | CHR | Position (hg19) | Gene | Annotation | Single-multi P value | Multi-multi P value (A Bonferroni-adjusted P value of discovery stage = 1.45 × 10−7) | ||||
|---|---|---|---|---|---|---|---|---|---|---|
Discovery | Replication | Meta P value | Discovery | Replication | Meta P value | |||||
rs7107152 | 11 | 117,056,080 | SIDT2 | Intronic | 2.59E-01 | 8.43E-01 | 5.51E-01 | 1.40E-08 | 2.32E-03 | 8.17E-10 |
rs1242229 | 11 | 117,062,370 | SIDT2 | Intronic | 5.39E-03 | 7.68E-02 | 3.64E-03 | |||
rs10892876 | 11 | 122,540,281 | UBASH3B | Intronic | 2.93E-01 | 1.27E-01 | 1.60E-01 | 3.34E-12 | 3.82E-03 | 4.21E-13 |
rs12290043 | 11 | 122,540,528 | UBASH3B | Intronic | 1.62E-01 | 1.46E-01 | 1.12E-01 | |||
rs886126 | 12 | 111,679,214 | CUX2 | Intronic | 3.51E-01 | 1.79E-01 | 2.37E-01 | 5.09E-13 | 3.35E-03 | 5.97E-14 |
rs2078851 | 12 | 111,690,579 | CUX2 | Intronic | 7.31E-05 | 6.63E-02 | 6.42E-05 | |||