Table 2 Aneuploidy and CNV detection in 15-pg DNA samples amplified using different WGA kits
From: Preimplantation genetic diagnosis and screening (PGD/S) using a semiconductor sequencing platform
CNV type | Mixing proportion | CNV length | Kits | |
|---|---|---|---|---|
SurePlex | DOP-PCR | |||
Aneuploidy | 1 | NA | 2/2 | 2/2 |
CNV | 1 | < 4 Mb | 4/4 | 4/4 |
4–10 Mb | 1/1 | 1/1 | ||
> 10 Mb | 1/1 | 1/1 | ||
Mixing CNV | 0.3 | < 4 Mb | 0/1 | 0/1 |
4–10 Mb | 2/3 | 2/3 | ||
> 10 Mb | 8/9 | 9/9 | ||
0.7 | < 4 Mb | 0/0 | 0/0 | |
4–10 Mb | 5/5 | 5/5 | ||
> 10 Mb | 8/8 | 8/8 | ||
Mixing Aneuploidy | 0.3 | NA | 4/4 | 4/4 |
0.7 | NA | 4/4 | 4/4 | |