The association of functional polymorphisms in genes expressed in endothelial cells and smooth muscle cells with the myocardial infarction

Table 6 Characteristics of included studies on HIF1A polymorphisms and MI or CAD risk included in the meta-analysis

Cite	First author	Year	Ethnicity	Country/Region	Case	Control	Genotype distribution						Genotyping methods	Disease	p for HWE^a
Cite	First author	Year	Ethnicity	Country/Region	Case	Control	Case		Control				Genotyping methods	Disease	p for HWE^a
							rs2057482 C > T
							CC	CT	TT	CC	CT	TT
Caucasian
[28]	Hlatky	2007	Caucasian	California	909	466	641	239	29	309	134	23	TaqMan	AMI	0.09
[1]	Lopez-Reyes	2014	Caucasian	Mexico	949	676	809	134	6	547	120	9	TaqMan	CAD	0.41
[29]	Duran	2015	Caucasian	Spain	497	111	339	148	10	70	38	3	TaqMan	CAD	0.42
Asian
[30]	Zheng	2009	Asian	Korea	14	361	8	5	1	233	117	11	SNaPShot	AMI	0.42
[15]	Guo	2017	Asian	China	589	860	476	93	20	726	125	9	TaqMan	CAD	0.17
							rs11549465 C > T
							CC	CT	TT	CC	CT	TT
[28]	Hlatky	2007	Caucasian	California	909	466	747	151	11	358	97	11	TaqMan	AMI	0.16
[30]	Zheng	2009	Asian	Korea	14	360	13	1	0	325	33	2	SNaPShot	AMI	0.26
[31]	Liu	2013	Asian	China	356	213	346	10	0	208	5	0	PCR	CAD	0.86
[29]	Duran	2015	Caucasian	Spain	518	112	402	111	5	84	26	2	TaqMan	CAD	0.99
[15]	Guo	2017	Asian	China	589	860	324	10	255	449	11	400	TaqMan	CAD	0.00
							rs10873142 T > C
							TT	TC	CC	TT	TC	CC
[28]	Hlatky	2007	Caucasian	California	909	466	549	305	55	249	174	43	TaqMan	AMI	0.12
[30]	Zheng	2009	Asian	Korea	14	360	7	6	1	199	141	20	SNaPShot	AMI	0.44
[15]	Guo	2017	Asian	China	609	860	355	209	45	442	347	71	TaqMan	CAD	0.80
							rs11549467 G > A
							GG	GA	AA	GG	GA	AA
[28]	Hlatky	2007	Caucasian	California	909	466	900	9	0	456	10	0	TaqMan	AMI	0.81
[31]	Liu	2013	Asian	China	356	213	340	16	0	204	9	0	PCR	CAD	0.75
[15]	Guo	2017	Asian	China	589	860	326	17	246	454	19	387	TaqMan	CAD	0.00
							rs41508050 C > T
							CC	CT	TT	CC	CT	TT
[28]	Hlatky	2007	Caucasian	California	909	466	903	6	0	457	9	0	TaqMan	AMI	0.83
[15]	Guo	2017	Asian	China	589	860	581	8	0	843	17	0	TaqMan	CAD	0.77

^aHWE in control; AMI acute myocardial infarction, CAD coronary artery disease
p values under 0.05 where shown in italic font

ISSN: 1479-7364