A genome-wide association study of mitochondrial DNA copy number in two population-based cohorts

Table 3 General concordance of association at rs709591, before adjustment for cell proportions

Cohort	Group	Subgroup	P	Info score (imputation quality)	β	SE	N
Unadjusted
ALSPAC	Mothers	All	1.05E−06	0.998	− 0.086	0.018	5461
	Mothers	White cell samples	6.26E−04	0.998	− 0.081	0.024	3405
	Children^b	All	0.524	0.998	− 0.015	0.024	3647
	Neonates^b	All	1.36E−04	0.998	− 0.119	0.031	2102
UKBS	All	Females	0.056	0.999	− 0.073	0.038	1338
UKBS	All	Males	0.025	0.999	− 0.090	0.040	1333
Cell-proportion adjusted (see Table 1 for covariates)
ALSPAC^a	Mothers	All	0.829	0.997	0.012	0.057	546
	Mothers	White cell samples	0.774	0.999	0.024	0.085	301
	Children^b	All	0.702	0.998	0.019	0.051	606
	Neonates^b	All	0.661	1.000	− 0.08	0.18	82
UKBS	All	Females	0.278	0.999	− 0.044	0.041	1138
UKBS	All	Males	0.241	0.999	− 0.049	0.042	1122

^aNB large drop in power for ALSPAC in cell proportion adjusted analyses (see Table 1)
^bSome children in these analyses are related to ALSPAC mothers, however, in N = 2833 unrelated ALSPAC mothers, this association persisted (β [SE] − 0.120 [0.024], p = 4.01e−07)

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