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Table 2 Gene ontology terms associated with differentially regulated genes in Le-Cre lenses

From: Considerations for the use of Cre recombinase for conditional gene deletion in the mouse lens

GO term Count p value Genes
Negative regulation of cell proliferation 4 3.6 × 10−3 Cdkn1a, Hmox1, Serpine2, Trp53inp1
Negative regulation of cell growth 3 4.7 × 10−3 Cdkn1a, Hyal1, Serpine2
Cellular response to UV-B 2 6.6 × 10−3 Cdkn1a, Hyal1
Intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator 2 2.5 × 10− 2 Cdkn1a, Phlda3
Positive regulation of apoptotic process 3 3.1 × 10−2 Hmox1, Phlda3, Trp53inp1
Cellular response to heat 2 3.2 × 10−2 Cdkn1a, Hmox1
Negative regulation of signal transduction 2 4.3 × 10−2 Ddit4l, Rgs8
Cell cycle arrest 2 6.5 × 10−2 Cdkn1a, Trp53inp1
Response to toxic substance 2 6.9 × 10−2 Cdkn1a, Ephx1
Apoptotic process 3 7.9 × 10−2 Hmox1, Phlda3, Trp53inp1
Positive regulation of angiogenesis 2 9.6 × 10−2 Hmox1, Hyal1