Table 2 Gene ontology terms associated with differentially regulated genes in Le-Cre lenses
From: Considerations for the use of Cre recombinase for conditional gene deletion in the mouse lens
GO term | Count | p value | Genes |
|---|---|---|---|
Negative regulation of cell proliferation | 4 | 3.6 × 10−3 | Cdkn1a, Hmox1, Serpine2, Trp53inp1 |
Negative regulation of cell growth | 3 | 4.7 × 10−3 | Cdkn1a, Hyal1, Serpine2 |
Cellular response to UV-B | 2 | 6.6 × 10−3 | Cdkn1a, Hyal1 |
Intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator | 2 | 2.5 × 10− 2 | Cdkn1a, Phlda3 |
Positive regulation of apoptotic process | 3 | 3.1 × 10−2 | Hmox1, Phlda3, Trp53inp1 |
Cellular response to heat | 2 | 3.2 × 10−2 | Cdkn1a, Hmox1 |
Negative regulation of signal transduction | 2 | 4.3 × 10−2 | Ddit4l, Rgs8 |
Cell cycle arrest | 2 | 6.5 × 10−2 | Cdkn1a, Trp53inp1 |
Response to toxic substance | 2 | 6.9 × 10−2 | Cdkn1a, Ephx1 |
Apoptotic process | 3 | 7.9 × 10−2 | Hmox1, Phlda3, Trp53inp1 |
Positive regulation of angiogenesis | 2 | 9.6 × 10−2 | Hmox1, Hyal1 |