Table 4 Distribution of tumor characteristics by ancestral population among patients with CRC
From: Association of genetic ancestry with colorectal tumor location in Puerto Rican Latinos
European ancestrya | African ancestrya | Amerindian ancestrya | |||||||
|---|---|---|---|---|---|---|---|---|---|
Tumor characteristic | ≤ 0.63 n (%) | > 0.63 n (%) | p value* | ≤ 0.18 n (%) | > 0.18 n (%) | p value* | ≤ 0.17 n (%) | > 0.17 n (%) | p value* |
Tumor location (n = 336) | |||||||||
Proximal | 40 (22.22) | 32 (20.51) | 0.53 | 40 (25.64) | 32 (17.78) | 0.11 | 29 (19.85) | 43 (23.50) | 0.03 |
Distal | 39 (21.67) | 42 (26.92) | 40 (25.64) | 41 (22.78) | 29 (18.95) | 52 (28.42) | |||
Rectum | 101 (56.11) | 82 (52.56) | 76 (48.72) | 107 (59.44) | 95 (62.09) | 88 (48.09) | |||
Tumor stage (n = 266) | |||||||||
0/ I/II | 70 (51.09) | 59 (45.74) | 0.55 | 60 (46.51) | 69 (50.36) | 0.74 | 55 (49.55) | 74 (47.74) | 0.89 |
III/IV | 53 (38.69) | 52 (40.31) | 54 (41.86) | 51 (37.23) | 42 (37.84) | 63 (40.65) | |||
Other/unknown | 14 (10.22) | 18 (13.95) | 15 (11.63) | 17 (12.41) | 14 (12.61) | 18 (11.61) | |||
Tumor differentiation (n = 250) | |||||||||
High | 27 (20.77) | 31 (25.83) | 0.34 | 33 (27.05) | 25 (19.53) | 0.16 | 24 (22.43) | 34 (23.78) | 0.80 |
Low/moderate | 103 (79.23) | 89 (74.17) | 89 (72.95) | 103 (80.47) | 83 (77.57) | 109 (76.22) | |||
Microsatellite status (n = 108) | |||||||||
Stable | 51 (98.08) | 52 (92.86) | 0.37 | 51 (92.73) | 52 (98.11) | 0.36 | 47 (95.92) | 56 (94.92) | 0.99 |
Low/high | 1 (1.92) | 4 (7.14) | 4 (7.27) | 1 (1.89) | 2 (4.08) | 3 (5.08) | |||
CIMP status (n = 83) | |||||||||
Absent | 6 (12.50) | 3 (8.57) | 0.73 | 2 (6.06) | 7 (14.00) | 0.31 | 6 (13.04) | 3 (8.11) | 0.73 |
Low | 42 (87.50) | 32 (91.43) | 31 (93.94) | 43 (86.00) | 40 (86.96) | 34 (91.89) | |||
KRAS mutation status (n = 109) | |||||||||
Wild type | 35 (64.81) | 39 (70.91) | 0.50 | 37 (69.81) | 37 (66.07) | 0.68 | 31 (57.41) | 43 (78.18) | 0.02 |
Mutated | 19 (35.19) | 16 (29.09) | 16 (30.19) | 19 (33.93) | 23 (42.59) | 12 (21.82) | |||
BRAF mutation status (n = 106) | |||||||||
Wild type | 51 (96.23) | 47 (88.68) | 0.27 | 49 (96.08) | 49 (89.09) | 0.27 | 49 (89.09) | 49 (96.08) | 0.27 |
Mutated | 2 (3.77) | 6 (11.32) | 2 (3.92) | 6 (10.91) | 6 (10.91) | 2 (3.92) | |||