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Table 4 Distribution of tumor characteristics by ancestral population among patients with CRC

From: Association of genetic ancestry with colorectal tumor location in Puerto Rican Latinos

  European ancestrya African ancestrya Amerindian ancestrya
Tumor characteristic ≤ 0.63
n (%)
> 0.63
n (%)
p value* ≤  0.18
n (%)
> 0.18
n (%)
p value* ≤  0.17
n (%)
> 0.17
n (%)
p value*
Tumor location (n = 336)
 Proximal 40 (22.22) 32 (20.51) 0.53 40 (25.64) 32 (17.78) 0.11 29 (19.85) 43 (23.50) 0.03
 Distal 39 (21.67) 42 (26.92) 40 (25.64) 41 (22.78) 29 (18.95) 52 (28.42)
 Rectum 101 (56.11) 82 (52.56)   76 (48.72) 107 (59.44)   95 (62.09) 88 (48.09)  
Tumor stage (n = 266)
 0/ I/II 70 (51.09) 59 (45.74) 0.55 60 (46.51) 69 (50.36) 0.74 55 (49.55) 74 (47.74) 0.89
 III/IV 53 (38.69) 52 (40.31) 54 (41.86) 51 (37.23) 42 (37.84) 63 (40.65)
 Other/unknown 14 (10.22) 18 (13.95) 15 (11.63) 17 (12.41) 14 (12.61) 18 (11.61)
Tumor differentiation (n = 250)
 High 27 (20.77) 31 (25.83) 0.34 33 (27.05) 25 (19.53) 0.16 24 (22.43) 34 (23.78) 0.80
 Low/moderate 103 (79.23) 89 (74.17) 89 (72.95) 103 (80.47) 83 (77.57) 109 (76.22)
Microsatellite status (n = 108)
 Stable 51 (98.08) 52 (92.86) 0.37 51 (92.73) 52 (98.11) 0.36 47 (95.92) 56 (94.92) 0.99
 Low/high 1 (1.92) 4 (7.14) 4 (7.27) 1 (1.89) 2 (4.08) 3 (5.08)
CIMP status (n = 83)
 Absent 6 (12.50) 3 (8.57) 0.73 2 (6.06) 7 (14.00) 0.31 6 (13.04) 3 (8.11) 0.73
 Low 42 (87.50) 32 (91.43) 31 (93.94) 43 (86.00) 40 (86.96) 34 (91.89)
KRAS mutation status (n = 109)
 Wild type 35 (64.81) 39 (70.91) 0.50 37 (69.81) 37 (66.07) 0.68 31 (57.41) 43 (78.18) 0.02
 Mutated 19 (35.19) 16 (29.09) 16 (30.19) 19 (33.93) 23 (42.59) 12 (21.82)
BRAF mutation status (n = 106)
 Wild type 51 (96.23) 47 (88.68) 0.27 49 (96.08) 49 (89.09) 0.27 49 (89.09) 49 (96.08) 0.27
 Mutated 2 (3.77) 6 (11.32) 2 (3.92) 6 (10.91) 6 (10.91) 2 (3.92)
  1. *p value from chi-square or Fisher’s exact test
  2. aDichotomous variables were analyzed the median value of each ancestry marker among controls as a cut-off